UniProt Accession

 JAM1_MOUSE; O88792; Q8VC39 

Genbank Protein ID

 U89915; AK033574; CT010347; AC087229; BC021876 

Genbank Nucleotide ID

 AAC32982.1; BAC28369.1; CAJ18555.1; AAH21876.1 

Protein Name

 Junctional adhesion molecule A 

Protein Synonyms/Alias

 JAM-A; Junctional adhesion molecule 1; JAM-1; CD321 

Gene Name

 F11r 

Gene Synonyms/Alias

 Jam1; Jcam; Jcam1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
278	KGTAPGKKVIYSQPS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus (By similarity). 

Sequence Annotation

 DOMAIN 28 122 Ig-like V-type 1.
 DOMAIN 134 230 Ig-like V-type 2.
 MOD_RES 282 282 Phosphoserine (By similarity).
 MOD_RES 285 285 Phosphoserine.
 MOD_RES 288 288 Phosphoserine.
 CARBOHYD 42 42 N-linked (GlcNAc...).
 CARBOHYD 185 185 N-linked (GlcNAc...).
 DISULFID 49 108
 DISULFID 152 212  

Keyword

 3D-structure; Cell junction; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Host-virus interaction; Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome; Repeat; Signal; Tight junction; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 300 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005923; C:tight junction; IMP:MGI.
 GO:0007155; P:cell adhesion; IDA:MGI.
 GO:0030855; P:epithelial cell differentiation; IDA:MGI.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003598; Ig_sub2.
 IPR003596; Ig_V-set_subgr. 

Pfam

 PF07679; I-set 

SMART

 SM00408; IGc2
 SM00406; IGv 

PROSITE

 PS50835; IG_LIKE 

PRINTS