UniProt Accession

 DHAS_YEAST; P13663; D6VSD8 

Genbank Protein ID

 X15649; Z50046; AY557698; BK006938 

Genbank Nucleotide ID

 CAA33675.1; CAA90378.1; AAS56024.1; DAA11998.1 

Protein Name

 Aspartate-semialdehyde dehydrogenase 

Protein Synonyms/Alias

 ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase 

Gene Name

 HOM2 

Gene Synonyms/Alias

 YDR158W; YD8358.12 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
45	SSRSAGKKYVDAVNW	acetylation	[1]
234	AEDKTHVKLLTPEEI	acetylation	[1]
242	LLTPEEIKVSAQCNR	ubiquitination	[2]
265	ECISLRFKNRPAPSV	acetylation	[1]
265	ECISLRFKNRPAPSV	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity). 

Sequence Annotation

 NP_BIND 13 16 NADP (By similarity).
 NP_BIND 40 41 NADP (By similarity).
 NP_BIND 187 188 NADP (By similarity).
 NP_BIND 343 344 NADP (By similarity).
 ACT_SITE 156 156 Acyl-thioester intermediate (By
 ACT_SITE 256 256 Proton acceptor (By similarity).
 BINDING 112 112 Phosphate (By similarity).
 BINDING 184 184 Substrate (By similarity).
 BINDING 211 211 Substrate (By similarity).
 BINDING 214 214 Phosphate (By similarity).
 BINDING 249 249 Substrate (By similarity).
 MOD_RES 13 13 Phosphothreonine.
 MOD_RES 318 318 Phosphoserine.
 MOD_RES 323 323 Phosphoserine.  

Keyword

 Amino-acid biosynthesis; Complete proteome; Lysine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Phosphoprotein; Reference proteome; Threonine biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 365 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005886; C:plasma membrane; IDA:SGD.
 GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IDA:SGD.
 GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase activity; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0006531; P:aspartate metabolic process; IEA:InterPro.
 GO:0009090; P:homoserine biosynthetic process; IMP:SGD.
 GO:0009097; P:isoleucine biosynthetic process; IEA:InterPro.
 GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
 GO:0009086; P:methionine biosynthetic process; IMP:SGD.
 GO:0009088; P:threonine biosynthetic process; IMP:SGD. 

Interpro

 IPR000319; Asp-semialdehyde_DH_CS.
 IPR005676; Asp_semi-ald_DH_pep-lack.
 IPR012080; Asp_semialdehyde_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR000534; Semialdehyde_DH_NAD-bd.
 IPR012280; Semialdhyde_DH_dimer_dom. 

Pfam

 PF01118; Semialdhyde_dh
 PF02774; Semialdhyde_dhC 

SMART

 SM00859; Semialdhyde_dh 

PROSITE

 PS01103; ASD 

PRINTS