CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015542
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rho GTPase-activating protein 36 
Protein Synonyms/Alias
  
Gene Name
 ARHGAP36 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
31LSELERLKLQETAYHubiquitination[1]
50RHFLSEFKPDRALPIubiquitination[1]
411QVAKRVWKSSPEALDubiquitination[1]
434KIQSARIKMEEDALLubiquitination[1]
460AAVLAQSKPSDEGSSubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state (By similarity). 
Sequence Annotation
 DOMAIN 226 426 Rho-GAP.  
Keyword
 Alternative splicing; Complete proteome; GTPase activation; Reference proteome; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 547 AA 
Protein Sequence
MSVLGGAPGH NPDRRTKMVS IHSLSELERL KLQETAYHEL VARHFLSEFK PDRALPIDRP 60
NTLDKWFLIL RGQQRAVSHK TFGISLEEVL VNEFTRRKHL ELTATMQVEE ATGQAAGRRR 120
GNVVRRVFGR IRRFFSRRRN EPTLPREFTR RGRRGAVSVD SLAELEDGAL LLQTLQLSKI 180
SFPIGQRLLG SKRKMSLNPI AKQIPQVVEA CCQFIEKHGL SAVGIFTLEY SVQRVRQLRE 240
EFDQGLDVVL DDNQNVHDVA ALLKEFFRDM KDSLLPDDLY MSFLLTATLK PQDQLSALQL 300
LVYLMPPCHS DTLERLLKAL HKITENCEDS IGIDGQLVPG NRMTSTNLAL VFGSALLKKG 360
KFGKRESRKT KLGIDHYVAS VNVVRAMIDN WDVLFQVPPH IQRQVAKRVW KSSPEALDFI 420
RRRNLRKIQS ARIKMEEDAL LSDPVETSAE ARAAVLAQSK PSDEGSSEEP AVPSGTARSH 480
DDEEGAGNPP IPEQDRPLLR VPREKEAKTG VSYFFP 516 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
 GO:0043547; P:positive regulation of GTPase activity; IEA:GOC.
 GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.
 GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. 
Interpro
 IPR008936; Rho_GTPase_activation_prot.
 IPR000198; RhoGAP_dom. 
Pfam
 PF00620; RhoGAP 
SMART
 SM00324; RhoGAP 
PROSITE
 PS50238; RHOGAP 
PRINTS