| Tag | Content |
|---|
| CPLM ID | CPLM-015493 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein lin-28 homolog B |
Protein Synonyms/Alias | Lin-28B |
Gene Name | LIN28B |
Gene Synonyms/Alias | CSDD2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 240 | APEEQSKKGPSVQKR | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. |
Sequence Annotation | DOMAIN 29 102 CSD.
ZN_FING 127 144 CCHC-type 1.
ZN_FING 149 166 CCHC-type 2.
METAL 129 129 Zinc 1 (By similarity).
METAL 132 132 Zinc 1 (By similarity).
METAL 137 137 Zinc 1 (By similarity).
METAL 142 142 Zinc 1 (By similarity).
METAL 151 151 Zinc 2 (By similarity).
METAL 154 154 Zinc 2 (By similarity).
METAL 159 159 Zinc 2 (By similarity).
METAL 164 164 Zinc 2 (By similarity). |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Repeat; RNA-binding; RNA-mediated gene silencing; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 250 AA |
Protein Sequence | MAEGGASKGG GEEPGKLPEP AEEESQVLRG TGHCKWFNVR MGFGFISMIN REGSPLDIPV 60
DVFVHQSKLF MEGFRSLKEG EPVEFTFKKS SKGLESIRVT GPGGSPCLGS ERRPKGKTLQ 120
KRKPKGDRCY NCGGLDHHAK ECSLPPQPKK CHYCQSIMHM VANCPHKNVA QPPASSQGRQ 180
EAESQPCTST LPREVGGGHG CTSPPFPQEA RAEISERSGR SPQEASSTKS SIAPEEQSKK 240
GPSVQKRKKT 250 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |