CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014785
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein virilizer homolog 
Protein Synonyms/Alias
  
Gene Name
 KIAA1429 
Gene Synonyms/Alias
 MSTP054 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
16LLFLDTFKHPSAEQSubiquitination[1]
105IIFRPNSKVNTDGLVubiquitination[2, 3, 4]
367EIEISRMKDQGPDKEubiquitination[1]
373MKDQGPDKENSGAIEubiquitination[2]
399YREDRGAKWVTALEEubiquitination[1, 4]
556AGSAILQKCHFYEVLubiquitination[1]
576LGDHLAEKTSSLPNHubiquitination[1, 2, 3, 4]
887KADENNAKLQELGKWubiquitination[2]
899GKWLEPLKNLRFEINubiquitination[1, 2, 5, 6]
1029RGGSFEFKDMRVPSAubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
 May be involved in mRNA splicing regulation (By similarity). 
Sequence Annotation
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 133 133 Phosphoserine.
 MOD_RES 138 138 Phosphoserine.
 MOD_RES 173 173 Phosphoserine.
 MOD_RES 184 184 Phosphothreonine.
 MOD_RES 222 222 Phosphoserine.
 MOD_RES 914 914 Phosphotyrosine.
 MOD_RES 1579 1579 Phosphoserine.
 MOD_RES 1708 1708 Phosphothreonine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1812 AA 
Protein Sequence
MAVDSAMELL FLDTFKHPSA EQSSHIDVVR FPCVVYINEV RVIPPGVRAH SSLPDNRAYG 60
ETSPHTFQLD LFFNNVSKPS APVFDRLGSL EYDENTSIIF RPNSKVNTDG LVLRGWYNCL 120
TLAIYGSVDR VISHDRDSPP PPPPPPPPPQ PQPSLKRNPK HADGEKEDQF NGSPPRPQPR 180
GPRTPPGPPP PDDDEDDPVP LPVSGDKEED APHREDYFEP ISPDRNSVPQ EGQYSDEGEV 240
EEEQQEEGEE DEDDVDVEEE EDEDEDDRRT VDSIPEEEEE DEEEEGEEDE EGEGDDGYEQ 300
ISSDEDGIAD LERETFKYPN FDVEYTAEDL ASVPPMTYDP YDRELVPLLY FSCPYKTTFE 360
IEISRMKDQG PDKENSGAIE ASVKLTELLD LYREDRGAKW VTALEEIPSL IIKGLSYLQL 420
KNTKQDSLGQ LVDWTMQALN LQVALRQPIA LNVRQLKAGT KLVSSLAECG AQGVTGLLQA 480
GVISGLFELL FADHVSSSLK LNAFKALDSV ISMTEGMEAF LRGRQNEKSG YQKLLELILL 540
DQTVRVVTAG SAILQKCHFY EVLSEIKRLG DHLAEKTSSL PNHSEPDHDT DAGLERTNPE 600
YENEVEASMD MDLLESSNIS EGEIERLINL LEEVFHLMET APHTMIQQPV KSFPTMARIT 660
GPPERDDPYP VLFRYLHSHH FLELVTLLLS IPVTSAHPGV LQATKDVLKF LAQSQKGLLF 720
FMSEYEATNL LIRALCHFYD QDEEEGLQSD GVIDDAFALW LQDSTQTLQC ITELFSHFQR 780
CTASEETDHS DLLGTLHNLY LITFNPVGRS AVGHVFSLEK NLQSLITLME YYSKEALGDS 840
KSKKSVAYNY ACILILVVVQ SSSDVQMLEQ HAASLLKLCK ADENNAKLQE LGKWLEPLKN 900
LRFEINCIPN LIEYVKQNID NLMTPEGVGL TTALRVLCNV ACPPPPVEGQ QKDLKWNLAV 960
IQLFSAEGMD TFIRVLQKLN SILTQPWRLH VNMGTTLHRV TTISMARCTL TLLKTMLTEL 1020
LRGGSFEFKD MRVPSALVTL HMLLCSIPLS GRLDSDEQKI QNDIIDILLT FTQGVNEKLT 1080
ISEETLANNT WSLMLKEVLS SILKVPEGFF SGLILLSELL PLPLPMQTTQ VIEPHDISVA 1140
LNTRKLWSMH LHVQAKLLQE IVRSFSGTTC QPIQHMLRRI CVQLCDLASP TALLIMRTVL 1200
DLIVEDLQST SEDKEKQYTS QTTRLLALLD ALASHKACKL AILHLINGTI KGDERYAEIF 1260
QDLLALVRSP GDSVIRQQCV EYVTSILQSL CDQDIALILP SSSEGSISEL EQLSNSLPNK 1320
ELMTSICDCL LATLANSESS YNCLLTCVRT MMFLAEHDYG LFHLKSSLRK NSSALHSLLK 1380
RVVSTFSKDT GELASSFLEF MRQILNSDTI GCCGDDNGLM EVEGAHTSRT MSINAAELKQ 1440
LLQSKEESPE NLFLELEKLV LEHSKDDDNL DSLLDSVVGL KQMLESSGDP LPLSDQDVEP 1500
VLSAPESLQN LFNNRTAYVL ADVMDDQLKS MWFTPFQAEE IDTDLDLVKV DLIELSEKCC 1560
SDFDLHSELE RSFLSEPSSP GRTKTTKGFK LGKHKHETFI TSSGKSEYIE PAKRAHVVPP 1620
PRGRGRGGFG QGIRPHDIFR QRKQNTSRPP SMHVDDFVAA ESKEVVPQDG IPPPKRPLKV 1680
SQKISSRGGF SGNRGGRGAF HSQNRFFTPP ASKGNYSRRE GTRGSSWSAQ NTPRGNYNES 1740
RGGQSNFNRG PLPPLRPLSS TGYRPSPRDR ASRGRGGLGP SWASANSGSG GSRGKFVSGG 1800
SGRGRHVRSF TR 1812 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR026736; Virilizer. 
Pfam
  
SMART
  
PROSITE
  
PRINTS