CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007370
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 D-3-phosphoglycerate dehydrogenase 2 
Protein Synonyms/Alias
 3-PGDH 2 
Gene Name
 SER33 
Gene Synonyms/Alias
 YIL074C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
86GYQVEFHKSSLPEDEacetylation[1]
115SKTRLTEKILQHARNacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
  
Sequence Annotation
 DOMAIN 399 469 ACT.
 NP_BIND 208 209 NAD (By similarity).
 NP_BIND 285 287 NAD (By similarity).
 NP_BIND 347 350 NAD (By similarity).
 ACT_SITE 287 287 By similarity.
 ACT_SITE 316 316 By similarity.
 ACT_SITE 347 347 Proton donor (By similarity).
 BINDING 228 228 NAD (By similarity).
 BINDING 311 311 NAD (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 22 22 Phosphoserine (By similarity).
 MOD_RES 29 29 Phosphoserine.
 MOD_RES 33 33 Phosphoserine.  
Keyword
 Acetylation; Amino-acid biosynthesis; Complete proteome; NAD; Oxidoreductase; Phosphoprotein; Reference proteome; Serine biosynthesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 469 AA 
Protein Sequence
MSYSAADNLQ DSFQRAMNFS GSPGAVSTSP TQSFMNTLPR RVSITKQPKA LKPFSTGDMN 60
ILLLENVNAT AIKIFKDQGY QVEFHKSSLP EDELIEKIKD VHAIGIRSKT RLTEKILQHA 120
RNLVCIGCFC IGTNQVDLKY AASKGIAVFN SPFSNSRSVA ELVIGEIISL ARQLGDRSIE 180
LHTGTWNKVA ARCWEVRGKT LGIIGYGHIG SQLSVLAEAM GLHVLYYDIV TIMALGTARQ 240
VSTLDELLNK SDFVTLHVPA TPETEKMLSA PQFAAMKDGA YVINASRGTV VDIPSLIQAV 300
KANKIAGAAL DVYPHEPAKN GEGSFNDELN SWTSELVSLP NIILTPHIGG STEEAQSSIG 360
IEVATALSKY INEGNSVGSV NFPEVSLKSL DYDQENTVRV LYIHRNVPGV LKTVNDILSD 420
HNIEKQFSDS HGEIAYLMAD ISSVNQSEIK DIYEKLNQTS AKVSIRLLY 469 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0004617; F:phosphoglycerate dehydrogenase activity; IMP:SGD.
 GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW.
 GO:0009070; P:serine family amino acid biosynthetic process; IMP:SGD. 
Interpro
 IPR006139; D-isomer_2_OHA_DH_cat_dom.
 IPR006140; D-isomer_2_OHA_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00389; 2-Hacid_dh
 PF02826; 2-Hacid_dh_C 
SMART
  
PROSITE
 PS51671; ACT
 PS00065; D_2_HYDROXYACID_DH_1
 PS00670; D_2_HYDROXYACID_DH_2
 PS00671; D_2_HYDROXYACID_DH_3 
PRINTS