| Tag | Content |
|---|
| CPLM ID | CPLM-017248 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Condensin complex subunit 1 |
Protein Synonyms/Alias | Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; mCAP-D2; Non-SMC condensin I complex subunit D2; XCAP-D2 homolog |
Gene Name | Ncapd2 |
Gene Synonyms/Alias | Capd2; Cnap1; Kiaa0159 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 1278 | IIDEFEQKLRACHTR | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (By similarity). |
Sequence Annotation | REGION 1 593 Interaction with SMC2 and SMC4 (By
MOTIF 1332 1353 Bipartite nuclear localization signal (By
MOD_RES 20 20 Phosphoserine (By similarity).
MOD_RES 575 575 Phosphoserine (By similarity).
MOD_RES 1300 1300 Phosphoserine.
MOD_RES 1320 1320 Phosphoserine.
MOD_RES 1323 1323 Phosphoserine.
MOD_RES 1329 1329 Phosphothreonine; by CDK1 (By
MOD_RES 1358 1358 Phosphoserine (By similarity).
MOD_RES 1361 1361 Phosphoserine (By similarity).
MOD_RES 1362 1362 Phosphoserine (By similarity).
MOD_RES 1367 1367 Phosphoserine (By similarity).
MOD_RES 1375 1375 Phosphothreonine; by CDK1 (By
MOD_RES 1380 1380 Phosphothreonine; by CDK1 (By |
Keyword | Alternative splicing; Cell cycle; Cell division; Chromosome; Complete proteome; Cytoplasm; DNA condensation; Mitosis; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1392 AA |
Protein Sequence | MSPHNFEFHL PLSPEELLKS GGVNQYVVRE VLPVKHLSSQ LRAFQSAFRA QGPLAILEHF 60
DTVYSILHHF RSIEPGLKED TLEFLKKVVS RHSQELSSIL DDAALSGSDR SAHLNALKMN 120
CYALIRLLES FENMTSQTSL IDLDIGGKGK RARAKATLGF DWEEERQPVL QLLTQLLQLD 180
IRHLWNHSAI EEEFVSLVTG CCYRLLENPT ISHQKNRSTK EAIAHLLGVA LVRYNHMLSA 240
TVKIIQMLQH FEHLPPVLVT AVSLWATDYG MKSIVGEIVR EIGQKCPQEL SRDTAGAKGF 300
AAFLTELAER IPAVLMANMC ILLDHLDGEN YMMRNAVLAA IAEMVLQVLN GDQLEESARE 360
TRDQFLDILQ AHGHDVNSFV RSRVLQLFAR IVQQKALPLT RFQAVVALAV GRLADKSVLV 420
CKNAIQLLAS FLANNPFSCK LSDIDLAGPL QKEIQKLQEM RAQRRSAAAT AALDPEEEWD 480
AMLPELKSTL QQLLKLPQEE GDHQIADAET AEEVKGRIRQ LLAKASYKQA IVLTREATSH 540
FQESEPFSHT EPEENSFLNL LGLIFKGPEA STQDSHGDTD PGLTGSKDSP SVPEPEGSQS 600
NDELVKQEML VQYLQDAYGF SQKITEAIGI ISKMMYENTT TVVQEVIEFF VMVFQFGVPQ 660
ALFGVRRMLP LIWSKEPGVR EAVLNAYRQL YLNPKGDSAR AKAQTLIHNL SLLLVDASVG 720
TIQCLEEILC EFVQKDEVKP AVIQLLWERA TEKVPSSPLE RCSSVMLLGM MARGKPEIVG 780
SNLDALVRVG LDEKSPQDYR LAQQVCLAIA NISDRRKPSL GERHPPFRLP QEHRLFERLQ 840
DMVTKGFAHP DPLWIPFKEV AVTLTYQLAE SPDVLCAQML QGCAKQVLEK LEKNATEADP 900
KETAPRLPTF LLMNLLSLAG DVALQQLVHL EQAVSGELGR RRVLREEQEH RAKEPKEKTA 960
SSETTMEEEL GLVGGATADD TEAELIRSIC EKELLDGNQV LAAFVPLLLK VCNNPGLYSN 1020
PELCAAASLA LGKFCMISAP FCDSQLRLLF TMLEKSSLPT VRSNLMVATG DLAIRFPNLV 1080
DPWTPHLYAR LRDPAQQVRK TAGLVMTHLI LKDMVKVKGQ VSEMAVLLID PVPQIAALAK 1140
NFFNELSHKG NAIYNLLPDI ISRLSDPEGG VEEEPFHTIM KQLLSYITKD KQTESLVEKL 1200
CQRFRTARTE RQYRDLAYCM SQLPLTERGL QKMLDNFECF GDKLLDESVF SAFLSIVGKL 1260
RRGAKPEGKA IIDEFEQKLR ACHTRGMDGI EEFETGQGGS QRALSAKKPS AVSRLQPLTS 1320
VDSDNDFVTP KPRRTKPGRP QTQQRKKSQR KAKVVFLSDE SSEDELSAEM TEEETPKRTT 1380
PIRRASGRRH RS 1392 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |