UniProt Accession

 PTN2_HUMAN; P17706; A8K955; A8MXU3; Q96AU5; Q96HR2 

Genbank Protein ID

 M25393; M81478; EF445017; EF445017; AK292570; AP001077; AP002449; AP005482; CH471113; CH471113; BC008244; BC016727 

Genbank Nucleotide ID

 AAA65997.1; ACA06062.1; ACA06064.1; BAF85259.1; EAX01532.1; EAX01539.1; AAH08244.1; AAH16727.1 

Protein Name

 Tyrosine-protein phosphatase non-receptor type 2 

Protein Synonyms/Alias

 T-cell protein-tyrosine phosphatase; TCPTP 

Gene Name

 PTPN2 

Gene Synonyms/Alias

 PTPT 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
38	DYPHRVAKFPENRNR	acetylation	[1]
38	DYPHRVAKFPENRNR	ubiquitination	[2]
60	PYDHSRVKLQNAEND	ubiquitination	[2]
245	KGDDINIKQVLLNMR	ubiquitination	[2, 3]
294	KRWKELSKEDLSPAF	ubiquitination	[2]
312	PNKIMTEKYNGNRIG	acetylation	[1]
312	PNKIMTEKYNGNRIG	ubiquitination	[2]
324	RIGLEEEKLTGDRCT	ubiquitination	[2]
336	RCTGLSSKMQDTMEE	ubiquitination	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 DOMAIN 5 275 Tyrosine-protein phosphatase.
 REGION 216 222 Substrate binding (By similarity).
 ACT_SITE 216 216 Phosphocysteine intermediate (By
 BINDING 182 182 Substrate (By similarity).
 BINDING 260 260 Substrate (By similarity).
 MOD_RES 298 298 Phosphoserine.
 MOD_RES 304 304 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Endoplasmic reticulum; Hydrolase; Nucleus; Phosphoprotein; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 415 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IEA:Compara.
 GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB.
 GO:0008286; P:insulin receptor signaling pathway; IEA:Compara.
 GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.
 GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB.
 GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IMP:UniProtKB.
 GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome. 

Interpro

 IPR012265; Ptpn1/Ptpn2.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 

Pfam

 PF00102; Y_phosphatase 

SMART

 SM00194; PTPc 

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 

PRINTS

 PR00700; PRTYPHPHTASE.