| Tag | Content |
|---|
| CPLM ID | CPLM-017293 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Leucine-rich glioma-inactivated protein 1 |
Protein Synonyms/Alias | |
Gene Name | Lgi1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 160 | TLPKDIFKGLDSLTN | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. |
Sequence Annotation | DOMAIN 35 72 LRRNT.
REPEAT 92 113 LRR 1.
REPEAT 116 137 LRR 2.
REPEAT 140 161 LRR 3.
DOMAIN 173 223 LRRCT.
REPEAT 224 267 EAR 1.
REPEAT 270 313 EAR 2.
REPEAT 316 364 EAR 3.
REPEAT 365 415 EAR 4.
REPEAT 418 462 EAR 5.
REPEAT 463 506 EAR 6.
REPEAT 509 552 EAR 7.
CARBOHYD 192 192 N-linked (GlcNAc...) (Potential).
CARBOHYD 277 277 N-linked (GlcNAc...) (Potential).
CARBOHYD 422 422 N-linked (GlcNAc...) (Potential). |
Keyword | Cell junction; Complete proteome; Glycoprotein; Leucine-rich repeat; Reference proteome; Repeat; Secreted; Signal; Synapse. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 557 AA |
Protein Sequence | MESESIRRMG NACIPLKRIA YFLCLFSVVL LTEGKKPAKP KCPAVCTCSK DNALCENARS 60
IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS NSFDVISDDA FIGLPHLEYL 120
FIENNNIKSI SRHTFRGLKS LIHLSLANNN LQTLPKDIFK GLDSLTNVDL RGNSFNCDCK 180
LKWLVEWLGH TNATVEDIYC EGPPEYKKRK INSLSPKDFD CIITEFAKSQ DLPYQSLSID 240
TFSYLNDEYV VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IDTQLYVIVA 300
QLFGGSHIYK RDGFANKFIK IQDIEVLKIR KPNDIETFKI EDNWYFVVAD SSKAGFTTIY 360
KWNGNGFYSH QSLHAWYRDT DVEYLEIARP PLTLRTPHLI LSSSSQRPVI YQWSKATQLF 420
INQTDIPNME DVYAVKHFSV KGDVYICLTR FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ 480
PLQINNYQYA ILGSDYSFTQ VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS 540
FKGNTQIYKH VIVDLSA 557 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-KW. GO:0005615; C:extracellular space; IDA:UniProtKB. GO:0045202; C:synapse; IEA:UniProtKB-SubCell. GO:0007411; P:axon guidance; IEA:Compara. GO:0030307; P:positive regulation of cell growth; IEA:Compara. GO:0050806; P:positive regulation of synaptic transmission; IDA:UniProtKB. GO:0051260; P:protein homooligomerization; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |