CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012910
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Erythroid differentiation-related factor 1 
Protein Synonyms/Alias
  
Gene Name
 EDRF1 
Gene Synonyms/Alias
 C10orf137 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
135ENIKKLLKIPYSKSHubiquitination[1]
178TGDWTWLKEFYQRLIubiquitination[2, 3, 4]
301GEHSQGLKNDFVRNIubiquitination[3]
397ENSNFSTKVIKDIAQubiquitination[3]
637PSTPIPLKYEDESSRubiquitination[3]
694QLILKSSKAYYVLSDubiquitination[1, 2, 3, 4, 5]
774EEFHYQTKEDQEILHubiquitination[1]
1192IEDDTILKTNKHIYSubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965
Functional Description
 Transcription factor involved in erythroid differentiation. Involved in transcriptional activation of the globin gene. 
Sequence Annotation
 REPEAT 693 726 TPR 1.
 REPEAT 914 953 TPR 2.  
Keyword
 Activator; Alternative splicing; Complete proteome; Nucleus; Polymorphism; Reference proteome; Repeat; TPR repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1238 AA 
Protein Sequence
MGDAKEAGAE GPPAGAAARG GLSLLSQGES EESSAQGSAL FLGGNEVKSR AVVKYSSAPP 60
RTAFARLEEK TDLKLPPANW LRESAKLGPA GTTILGNSKK SKPFSSFGMA YDFIDSVGND 120
VDVVSDSENI KKLLKIPYSK SHVSMAVHRI GRTLLLDELD IQELFMRSSQ TGDWTWLKEF 180
YQRLIDQKWQ RKKKSKEHWY QKAILSKFLY YSINGDGAAQ PVSSTAEQQE SSSSDQTNDS 240
EGASWPAPFE MPSSVSEDPS ASSQGSEPLE PSYIVGHVAS APKEQNLITL FNDGEHSQGL 300
KNDFVRNILW TFEDIHMLVG SNMPIFGGGR YPAVSLRLRD NNKPINVLTG IDYWLDNLIC 360
NVPELVMCFH VNGIVQKYEM IKTEEIPNLE NSNFSTKVIK DIAQNILSFL KSNCTKEGHT 420
YWLFKASGSD IVKLYDLTTL CEETEDKYQN PFTMPVAILL YKVACNMMMK KNQNKKHYGT 480
IRTLLLNCLK LLDKSRHPQI IASANYMLSE LFQLDEPKKE ENSESPLNEN SDESYSEEEE 540
EMPDSDENGS YSTSSDPSDD SKAVAIIKSV GELSVPEKYK SIHQIRPSCA FPVCHDTEER 600
CRLVLSYVLE GLKSVDSSIK KESDLPAADP STPIPLKYED ESSRGGPEGL EKQMALFLDK 660
MGSLQKGNYS SQSGMIPGSW QHKMKLQLIL KSSKAYYVLS DAAMSLQKYG RALRYIKLAL 720
QSHDTYCCLC TNMLSEVLLF LSQYLTLCGD IQLMLAQNAN NRAAHLEEFH YQTKEDQEIL 780
HSLHRESSCQ GFAWATDLST DLESQLSVSC KCYEAANEIL QFSDLKSQNP EHYVQVLKRM 840
GNIRNEIGVF YMNQAAALQS ERLVSKSVSA AEQQLWKKSF SCFEKGIHNF ESIEDATNAA 900
LLLCNTGRLM RICAQAHCGA GDELKREFSP EEGLYYNKAI DYYLKALRSL GTRDIHPAVW 960
DSVNWELSTT YFTMATLQQD YAPLSRKAQE QIEKEVSEAM MKSLKYCDVD SVSARQPLCQ 1020
YRAATIHHRL ASMYHSCLRN QVGDEHLRKQ HRVLADLHYS KAAKLFQLLK DAPCELLRVQ 1080
LERVAFAEFQ MTSQNSNVGK LKTLSGALDI MVRTEHAFQL IQKELIEEFG QPKSGDAAAA 1140
ADASPSLNRE EVMKLLSIFE SRLSFLLLQS IKLLSSTKKK TSNNIEDDTI LKTNKHIYSQ 1200
LLRATANKTA TLLERINVIV HLLGQLAAGS AASSNAVQ 1238 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
  
Pfam
  
SMART
  
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS