UniProt Accession

 HA11_MOUSE; P01899 

Genbank Protein ID

 M18523; L36068; U47325; K00129 

Genbank Nucleotide ID

 AAA53200.1; AAA89206.1; AAB17603.1; AAA39580.1 

Protein Name

 H-2 class I histocompatibility antigen, D-B alpha chain 

Protein Synonyms/Alias

 H-2D(B) 

Gene Name

 H2-D1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
55	SVGYVDNKEFVRFDS	ubiquitination	[1]
170	AAQITRRKWEQSGAA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Involved in the presentation of foreign antigens to the immune system. 

Sequence Annotation

 DOMAIN 209 297 Ig-like C1-type.
 REGION 25 114 Alpha-1.
 REGION 115 206 Alpha-2.
 REGION 207 298 Alpha-3.
 REGION 299 309 Connecting peptide.
 CARBOHYD 110 110 N-linked (GlcNAc...).
 CARBOHYD 200 200 N-linked (GlcNAc...) (Probable).
 CARBOHYD 280 280 N-linked (GlcNAc...).
 DISULFID 125 188
 DISULFID 227 283
 CROSSLNK 353 353 Glycyl serine ester (Ser-Gly) (interchain  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunity; Membrane; MHC I; Reference proteome; Signal; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 362 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IDA:MGI.
 GO:0071556; C:integral to lumenal side of endoplasmic reticulum membrane; TAS:Reactome.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0030670; C:phagocytic vesicle membrane; TAS:Reactome.
 GO:0002485; P:antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; IDA:MGI.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IDA:MGI. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 

Pfam

 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS

 PR01638; MHCCLASSI.