CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000085
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Exocyst complex component 5 
Protein Synonyms/Alias
 Exocyst complex component Sec10; hSec10 
Gene Name
 EXOC5 
Gene Synonyms/Alias
 SEC10; SEC10L1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
132QRAVEAQKLMKYFNEubiquitination[1]
259ILCQRVNKQVGDIFSubiquitination[1]
388TGGIQDLKERIRQRTubiquitination[1]
556HILAAEQKKTDFKPEubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. 
Sequence Annotation
 MOD_RES 122 122 Phosphothreonine.
 MOD_RES 395 395 Phosphothreonine (By similarity).
 MOD_RES 405 405 Phosphothreonine (By similarity).
 MOD_RES 412 412 Phosphoserine (By similarity).  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Exocytosis; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 708 AA 
Protein Sequence
MATTAELFEE PFVADEYIER LVWRTPGGGS RGGPEAFDPK RLLEEFVNHI QELQIMDERI 60
QRKVEKLEQQ CQKEAKEFAK KVQELQKSNQ VAFQHFQELD EHISYVATKV CHLGDQLEGV 120
NTPRQRAVEA QKLMKYFNEF LDGELKSDVF TNSEKIKEAA DIIQKLHLIA QELPFDRFSE 180
VKSKIASKYH DLECQLIQEF TSAQRRGEIS RMREVAAVLL HFKGYSHCVD VYIKQCQEGA 240
YLRNDIFEDA GILCQRVNKQ VGDIFSNPET VLAKLIQNVF EIKLQSFVKE QLEECRKSDA 300
EQYLKNLYDL YTRTTNLSSK LMEFNLGTDK QTFLSKLIKS IFISYLENYI EVETGYLKSR 360
SAMILQRYYD SKNHQKRSIG TGGIQDLKER IRQRTNLPLG PSIDTHGETF LSQEVVVNLL 420
QETKQAFERC HRLSDPSDLP RNAFRIFTIL VEFLCIEHID YALETGLAGI PSSDSRNANL 480
YFLDVVQQAN TIFHLFDKQF NDHLMPLISS SPKLSECLQK KKEIIEQMEM KLDTGIDRTL 540
NCMIGQMKHI LAAEQKKTDF KPEDENNVLI QYTNACVKVC AYVRKQVEKI KNSMDGKNVD 600
TVLMELGVRF HRLIYEHLQQ YSYSCMGGML AICDVAEYRK CAKDFKIPMV LHLFDTLHAL 660
CNLLVVAPDN LKQVCSGEQL ANLDKNILHS FVQLRADYRS ARLARHFS 708 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0044267; P:cellular protein metabolic process; TAS:Reactome.
 GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:ProtInc.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0048278; P:vesicle docking; IEA:InterPro. 
Interpro
 IPR009976; Sec10-like. 
Pfam
 PF07393; Sec10 
SMART
  
PROSITE
  
PRINTS