| Tag | Content |
|---|
| CPLM ID | CPLM-020606 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Regulation of nuclear pre-mRNA domain-containing protein 1B |
Protein Synonyms/Alias | Cell cycle-related and expression-elevated protein in tumor |
Gene Name | Rprd1b |
Gene Synonyms/Alias | Crept |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 35 | LWLIHHRKHAGPIVS | acetylation | [1] |
|
Reference | [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways. Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y. Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [ PMID: 22826441] |
Functional Description | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation (By similarity). |
Sequence Annotation | DOMAIN 1 133 CID.
MOD_RES 134 134 Phosphoserine (By similarity).
MOD_RES 166 166 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 326 AA |
Protein Sequence | MSSFSESALE KKLSELSNSQ QSVQTLSLWL IHHRKHAGPI VSVWHRELRK AKSNRKLTFL 60
YLANDVIQNS KRKGPEFTRE FESVLVDAFS HVAREADEGC KKPLERLLNI WQERSVYGGE 120
FIQQLKLSME DSKSPPPKAA EEKKSLKRTF QQIQEEEDDD YPGSYSPQDP SAGPLLTEEL 180
IKALQDLENA ASGDATVRQK IASLPQEVQD VSLLEKITDK EAAERLSKTV DEACLLLAEY 240
NGRLAAELED RRQLARMLVE YTQNQKEVLS EKEKKLEEYK QKLARVTQVR KELKSHIQSL 300
PDLSLLPNVT GGLAPLPSAG DLFSTD 326 |
Gene Ontology | GO:0016591; C:DNA-directed RNA polymerase II, holoenzyme; ISS:UniProtKB. GO:0000993; F:RNA polymerase II core binding; ISS:UniProtKB. GO:0070940; P:dephosphorylation of RNA polymerase II C-terminal domain; ISS:UniProtKB. GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB. GO:0010564; P:regulation of cell cycle process; ISS:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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