CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014993
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Keratin, type II cytoskeletal 80 
Protein Synonyms/Alias
 Cytokeratin-80; CK-80; Keratin-80; K80; Type-II keratin Kb20 
Gene Name
 KRT80 
Gene Synonyms/Alias
 KB20 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
71LLVPLDVKLDPAVQQubiquitination[1, 2]
93EMKALNDKFASLIGKubiquitination[1, 2, 3]
100KFASLIGKVQALEQRubiquitination[2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572
Functional Description
  
Sequence Annotation
 REGION 1 82 Head.
 REGION 82 118 Coil 1A.
 REGION 83 390 Rod.
 REGION 119 135 Linker 1.
 REGION 136 227 Coil 1B.
 REGION 228 251 Linker 12.
 REGION 252 390 Coil 2.
 REGION 391 452 Tail.
 MOD_RES 45 45 Phosphoserine.
 MOD_RES 396 396 Phosphoserine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Intermediate filament; Keratin; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 452 AA 
Protein Sequence
MACRSCVVGF SSLSSCEVTP VGSPRPGTSG WDSCRAPGPG FSSRSLTGCW SAGTISKVTV 60
NPGLLVPLDV KLDPAVQQLK NQEKEEMKAL NDKFASLIGK VQALEQRNQL LETRWSFLQG 120
QDSAIFDLGH LYEEYQGRLQ EELRKVSQER GQLEANLLQV LEKVEEFRIR YEDEISKRTD 180
MEFTFVQLKK DLDAECLHRT ELETKLKSLE SFVELMKTIY EQELKDLAAQ VKDVSVTVGM 240
DSRCHIDLSG IVEEVKAQYD AVAARSLEEA EAYSRSQLEE QAARSAEYGS SLQSSRSEIA 300
DLNVRIQKLR SQILSVKSHC LKLEENIKTA EEQGELAFQD AKTKLAQLEA ALQQAKQDMA 360
RQLRKYQELM NVKLALDIEI ATYRKLVEGE EGRMDSPSAT VVSAVQSRCK TAASRSGLSK 420
APSRKKKGSK GPVIKITEMS EKYFSQESEV SE 452 
Gene Ontology
 GO:0045095; C:keratin filament; IEA:InterPro.
 GO:0005198; F:structural molecule activity; IEA:InterPro. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR003054; Keratin_II. 
Pfam
 PF00038; Filament 
SMART
  
PROSITE
 PS00226; IF 
PRINTS
 PR01276; TYPE2KERATIN.