UniProt Accession

 SEM1_YEAST; O94742; D6VSZ2 

Genbank Protein ID

 AF059310; AF065136; U28372; AY557719; BK006938 

Genbank Nucleotide ID

 AAD08804.1; AAC96096.1; AAS56045.1; DAA12202.1 

Protein Name

 26S proteasome complex subunit SEM1 

Protein Synonyms/Alias

  

Gene Name

 SEM1 

Gene Synonyms/Alias

 DSH1; YDR363W-A 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
13	AAAQAQSKIDLTKKK	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Versatile protein that might stabilize multiple protein complexes involved in diverse pathways. Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. Associates also with the TREX-2 complex that is required for transcription-coupled mRNA export, and the COP9 signalosome, which is involved in deneddylation. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.
 MOD_RES 12 12 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Phosphoprotein; Proteasome; Reference proteome; Transcription. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 89 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IPI:SGD.
 GO:0008541; C:proteasome regulatory particle, lid subcomplex; IDA:SGD.
 GO:0034515; C:proteasome storage granule; IDA:SGD.
 GO:0006887; P:exocytosis; IGI:SGD.
 GO:0030447; P:filamentous growth; IMP:SGD.
 GO:0006406; P:mRNA export from nucleus; IMP:SGD.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IDA:SGD.
 GO:0043248; P:proteasome assembly; IMP:SGD.
 GO:0051726; P:regulation of cell cycle; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007834; DSS1_SEM1. 

Pfam

 PF05160; DSS1_SEM1 

SMART

  

PROSITE

  

PRINTS