| Tag | Content |
|---|
| CPLM ID | CPLM-014561 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kynurenine formamidase |
Protein Synonyms/Alias | KFA; KFase; Arylformamidase; N-formylkynurenine formamidase; FKF |
Gene Name | AFMID |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 12 | SGVGFPSKVPWKKMS | ubiquitination | [1] | | 16 | FPSKVPWKKMSAEEL | ubiquitination | [1] | | 17 | PSKVPWKKMSAEELE | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites (By similarity). |
Sequence Annotation | MOTIF 95 99 HGGXW.
ACT_SITE 164 164 Nucleophile (By similarity).
ACT_SITE 247 247 By similarity.
ACT_SITE 279 279 By similarity. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Nucleus; Reference proteome; Tryptophan catabolism. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 303 AA |
Protein Sequence | MMDVSGVGFP SKVPWKKMSA EELENQYCPS RWVVRLGAEE ALRTYSQIGI EATTRARATR 60
KSLLHVPYGD GEGEKVDIYF PDESSEALPF FLFFHGGYWQ SGSKDESAFM VHPLTAQGVA 120
VVIVAYGIAP KGTLDHMVDQ VTRSVAFVQK RYPSNKGIYL CGHSAGAHLA AMMLLADWTK 180
HGVTPNLRGF FLVSGVFDLE PIVYTSQNVA LQLTLEDAQR NSPQLKVAQA QPVDPTCRVL 240
VVVGQFDSPE FHRQSWEFYQ VLPVQTLCQG EWKASFEELH DVDHFEIVEN LTQKDNVLTQ 300
IILKTIFQ 308 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0004061; F:arylformamidase activity; IEA:HAMAP. GO:0034354; P:de novo NAD biosynthetic process from tryptophan; IEA:HAMAP. GO:0006569; P:tryptophan catabolic process; TAS:Reactome. GO:0019441; P:tryptophan catabolic process to kynurenine; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |