CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037722
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calpain-1 catalytic subunit 
Protein Synonyms/Alias
  
Gene Name
 CAPN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
88FWSALLEKAYAKVNGubiquitination[1, 2]
124TEWYELRKAPSDLYQubiquitination[1, 3]
135DLYQIILKALERGSLubiquitination[2]
165ITFKKLVKGHAYSVTubiquitination[3]
175AYSVTGAKQVNYRGQubiquitination[1, 2, 3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 191 AA 
Protein Sequence
MCIPPAPGDC WLLAAIASLT LNDTLLHRVV PHGQSFQNGY AGIFHFQLWQ FGEWVDVVVD 60
DLLPIKDGKL VFVHSAEGNE FWSALLEKAY AKVNGSYEAL SGGSTSEGFE DFTGGVTEWY 120
ELRKAPSDLY QIILKALERG SLLGCSIDIS SVLDMEAITF KKLVKGHAYS VTGAKQVNYR 180
GQVVSLIRMR N 191 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:InterPro. 
Interpro
 IPR022684; Calpain_cysteine_protease.
 IPR001300; Peptidase_C2_calpain_cat. 
Pfam
 PF00648; Peptidase_C2 
SMART
 SM00230; CysPc 
PROSITE
 PS50203; CALPAIN_CAT 
PRINTS
 PR00704; CALPAIN.