Tag | Content |
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CPLM ID | CPLM-014047 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sorting nexin-3 |
Protein Synonyms/Alias | |
Gene Name | Snx3 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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95 | VVPPLPGKAFLRQLP | ubiquitination | [1] |
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Reference | [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J. J Proteome Res. 2012 Sep 7;11(9):4722-32. [ PMID: 22871113] |
Functional Description | Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation (By similarity). |
Sequence Annotation | DOMAIN 27 151 PX. BINDING 70 70 Phosphatidylinositol 3-phosphate (By BINDING 72 72 Phosphatidylinositol 3-phosphate; via BINDING 95 95 Phosphatidylinositol 3-phosphate (By BINDING 118 118 Phosphatidylinositol 3-phosphate (By MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 72 72 Phosphoserine (By similarity). |
Keyword | Acetylation; Complete proteome; Direct protein sequencing; Endosome; Lipid-binding; Phosphoprotein; Protein transport; Reference proteome; Transport; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 162 AA |
Protein Sequence | MAETVADTRR LITKPQNLND AYGPPSNFLE IDVSNPQTVG VGRGRFTTYE IRVKTNLPIF 60 KLKESTVRRR YSDFEWLRSE LERESKVVVP PLPGKAFLRQ LPFRGDDGIF DDNFIEERKQ 120 GLEQFINKVA GHPLAQNERC LHMFLQDEII DKSYTPSKIR HA 162 |
Gene Ontology | GO:0005769; C:early endosome; ISS:UniProtKB. GO:0010008; C:endosome membrane; ISS:UniProtKB. GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB. GO:0007154; P:cell communication; IEA:InterPro. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |