CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029966
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nuclear autoantigenic sperm protein 
Protein Synonyms/Alias
 Nuclear autoantigenic sperm protein (Histone-binding), isoform CRA_c 
Gene Name
 Nasp 
Gene Synonyms/Alias
 mCG_19661 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
76AASLLGKKYGETANEacetylation[1]
154VYDAMGEKEAKKAEGacetylation[2]
157AMGEKEAKKAEGKSLacetylation[2]
239QESLCTEKGKSISGAacetylation[3]
241SLCTEKGKSISGAYVacetylation[1, 3]
251SGAYVQNKEFRETVEacetylation[1, 3, 4]
284QPIRAAEKQGTLMKVacetylation[3]
487PNESVLEKKSLQENEubiquitination[5]
521IFKRQETKEAQLYAAubiquitination[5]
602KSIDVIEKRMAVLHEacetylation[1]
612AVLHEQMKEAEGSFTacetylation[1]
623GSFTEYEKEIEELKEubiquitination[5]
684VSMIASRKPTDGASSacetylation[3]
684VSMIASRKPTDGASSubiquitination[5]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 773 AA 
Protein Sequence
MATESTAAAA IAAELVSADK IEDAPAPSTS ADKMESLDVD SEAKKLLGLG QKHLVMGDIP 60
AAVNAFQEAA SLLGKKYGET ANECGEAFFF YGKSLLELAR MENGVLGNAL EGVHVEEEEG 120
EKTEDESLVE NNDNVDEEAR EELREQVYDA MGEKEAKKAE GKSLTKPETD KEQESEVEKG 180
GREDMDISEP EEKLQETVEP TSKQLTESSE EAKEAAIPGL NEDEVASGKT EQESLCTEKG 240
KSISGAYVQN KEFRETVEEG EEIISLEKKP KETSEDQPIR AAEKQGTLMK VVEIEAEIDP 300
QVKSADVGGE EPKDQVATSE SELGKAVLME LSGQDVEASP VVAAEAGAEV SEKPGQEITV 360
IPNNGPVVGQ STVGDQTPSE PQTSAERLTE TKDGSSVEEV KAELVPEQEE AMLPVEESEA 420
AGDGVETKVA QRATEKAPED KFKIAANEET QERDEQMKEG EETEGSEEED RENDKAEETP 480
NESVLEKKSL QENEEEEIGN LELAWDMLDL AKIIFKRQET KEAQLYAAQA HLKLGEVSVE 540
SENYIQAVEE FQACLSLQEQ YLEAHDRLLA ETHYQLGLAY GYNSQYDEAV AQFGKSIDVI 600
EKRMAVLHEQ MKEAEGSFTE YEKEIEELKE LLPEIREKIE DAKESQRSGN VAELALKATL 660
VESSTSGFTP SGAGASVSMI ASRKPTDGAS SSNCVTDISH LVRKKRKPEE ESPRKDDAKK 720
AKQEPEVNGG SGDAVSSGKE VSENMEAEAE NQAESQTAEG TVESAATIKS TAC 773 
Gene Ontology
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0042393; F:histone binding; IDA:MGI. 
Interpro
 IPR019544; Tetratricopeptide_SHNi-TPR_dom.
 IPR001440; TPR-1.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF10516; SHNi-TPR
 PF00515; TPR_1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS