CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016947
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ELKS/Rab6-interacting/CAST family member 1 
Protein Synonyms/Alias
 ERC-1; Rab6-interacting protein 2 
Gene Name
 ERC1 
Gene Synonyms/Alias
 ELKS; KIAA1081; RAB6IP2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
319LLEMLQSKGLSAKATubiquitination[1]
655DNYKKDLKDLKEKVSacetylation[2]
658KKDLKDLKEKVSLLQacetylation[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. 
Sequence Annotation
 DOMAIN 1046 1108 FIP-RBD.
 MOD_RES 17 17 Phosphoserine.
 MOD_RES 21 21 Phosphoserine.
 MOD_RES 37 37 Phosphoserine.
 MOD_RES 75 75 Phosphoserine.
 MOD_RES 94 94 Phosphoserine.
 MOD_RES 252 252 Phosphoserine (By similarity).
 MOD_RES 1046 1046 Phosphothreonine.  
Keyword
 Alternative splicing; Chromosomal rearrangement; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1116 AA 
Protein Sequence
MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGSSVGGGS GKTLSMENIQ 60
SLNAAYATSG PMYLSDHENV GSETPKSTMT LGRSGGRLPY GVRMTAMGSS PNIASSGVAS 120
DTIAFGEHHL PPVSMASTVP HSLRQARDNT IMDLQTQLKE VLRENDLLRK DVEVKESKLS 180
SSMNSIKTFW SPELKKERAL RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR 240
DLNQLFQQDS SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ 300
TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL EQKEKENSML 360
REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD LEEEIQMLKS NGALSTEERE 420
EEMKQMEVYR SHSKFMKNKV EQLKEELSSK EAQWEELKKK AAGLQAEIGQ VKQELSRKDT 480
ELLALQTKLE TLTNQFSDSK QHIEVLKESL TAKEQRAAIL QTEVDALRLR LEEKETMLNK 540
KTKQIQDMAE EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER 600
VKSLQADTTN TDTALTTLEE ALAEKERTIE RLKEQRDRDE REKQEEIDNY KKDLKDLKEK 660
VSLLQGDLSE KEASLLDLKE HASSLASSGL KKDSRLKTLE IALEQKKEEC LKMESQLKKA 720
HEAALEARAS PEMSDRIQHL EREITRYKDE SSKAQAEVDR LLEILKEVEN EKNDKDKKIA 780
ELERQVKDQN KKVANLKHKE QVEKKKSAQM LEEARRREDN LNDSSQQLQD SLRKKDDRIE 840
ELEEALRESV QITAEREMVL AQEESARTNA EKQVEELLMA MEKVKQELES MKAKLSSTQQ 900
SLAEKETHLT NLRAERRKHL EEVLEMKQEA LLAAISEKDA NIALLELSSS KKKTQEEVAA 960
LKREKDRLVQ QLKQQTQNRM KLMADNYEDD HFKSSHSNQT NHKPSPDQII QPLLELDQNR 1020
SKLKLYIGHL TTLCHDRDPL ILRGLTPPAS YNLDDDQAAW ENELQKMTRG QLQDELEKGE 1080
RDNAELQEFA NAILQQIADH CPDILEQVVN ALEESS 1116 
Gene Ontology
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0008385; C:IkappaB kinase complex; IDA:UniProtKB.
 GO:0042734; C:presynaptic membrane; TAS:UniProtKB.
 GO:0043522; F:leucine zipper domain binding; NAS:UniProtKB.
 GO:0007252; P:I-kappaB phosphorylation; IDA:UniProtKB.
 GO:0007275; P:multicellular organismal development; NAS:UniProtKB.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:0042147; P:retrograde transport, endosome to Golgi; IEA:Compara. 
Interpro
 IPR019323; CAZ_cplx_RIM-bd_prot.
 IPR019018; Rab-bd_FIP-RBD. 
Pfam
 PF10174; Cast
 PF09457; RBD-FIP 
SMART
  
PROSITE
 PS51511; FIP_RBD 
PRINTS