UniProt Accession

 H0YKL3_HUMAN; H0YKL3 

Genbank Protein ID

 AC012653; AC018904; AC025431; AC066616; AC084781 

Genbank Nucleotide ID

  

Protein Name

 Retinal dehydrogenase 2 

Protein Synonyms/Alias

  

Gene Name

 ALDH1A2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	ERGRLLDKLADLVER	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 85 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0004028; F:3-chloroallyl aldehyde dehydrogenase activity; IEA:Compara.
 GO:0016918; F:retinal binding; IEA:Compara.
 GO:0001758; F:retinal dehydrogenase activity; IEA:Compara.
 GO:0042904; P:9-cis-retinoic acid biosynthetic process; IEA:Compara.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0001568; P:blood vessel development; IEA:Compara.
 GO:0048738; P:cardiac muscle tissue development; IEA:Compara.
 GO:0071300; P:cellular response to retinoic acid; IEA:Compara.
 GO:0009855; P:determination of bilateral symmetry; IEA:Compara.
 GO:0031076; P:embryonic camera-type eye development; IEA:Compara.
 GO:0048566; P:embryonic digestive tract development; IEA:Compara.
 GO:0035115; P:embryonic forelimb morphogenesis; IEA:Compara.
 GO:0060324; P:face development; IEA:Compara.
 GO:0003007; P:heart morphogenesis; IEA:Compara.
 GO:0030902; P:hindbrain development; IEA:Compara.
 GO:0001822; P:kidney development; IEA:Compara.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0007494; P:midgut development; IEA:Compara.
 GO:0016331; P:morphogenesis of embryonic epithelium; IEA:Compara.
 GO:0014032; P:neural crest cell development; IEA:Compara.
 GO:0030182; P:neuron differentiation; IEA:Compara.
 GO:0031016; P:pancreas development; IEA:Compara.
 GO:0021983; P:pituitary gland development; IEA:Compara.
 GO:0043065; P:positive regulation of apoptotic process; IEA:Compara.
 GO:0008284; P:positive regulation of cell proliferation; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0009954; P:proximal/distal pattern formation; IEA:Compara.
 GO:0001936; P:regulation of endothelial cell proliferation; IEA:Compara.
 GO:0032355; P:response to estradiol stimulus; IEA:Compara.
 GO:0033189; P:response to vitamin A; IEA:Compara.
 GO:0042574; P:retinal metabolic process; IEA:Compara.
 GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Compara.
 GO:0035799; P:ureter maturation; IEA:Compara. 

Interpro

 IPR016161; Ald_DH/histidinol_DH.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 

Pfam

 PF00171; Aldedh 

SMART

  

PROSITE

  

PRINTS