| Tag | Content |
|---|
| CPLM ID | CPLM-016589 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Anaphase-promoting complex subunit 5 |
Protein Synonyms/Alias | APC5; Cyclosome subunit 5 |
Gene Name | Anapc5 |
Gene Synonyms/Alias | MNCb-2778 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 47 | VSLVERRKLNQLLLP | ubiquitination | [1] | | 209 | SQQAALLKNDETKAL | ubiquitination | [1] | | 223 | LTPASLQKELNNLLK | ubiquitination | [1] | | 274 | ILTGAEGKSNGEEGY | ubiquitination | [1] | | 388 | NKLMDALKDSDLLHW | ubiquitination | [1] | | 509 | DRAMNDGKFHLADSL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). |
Sequence Annotation | REPEAT 286 319 TPR 1.
REPEAT 507 540 TPR 2.
REPEAT 566 599 TPR 3.
REPEAT 663 696 TPR 4.
MOD_RES 180 180 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Cell cycle; Cell division; Complete proteome; Mitosis; Phosphoprotein; Reference proteome; Repeat; TPR repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 740 AA |
Protein Sequence | MMTNGVVHAN LFGIKDWVTP YKIAVLVLLN EMGRTGEGAV SLVERRKLNQ LLLPLLQGPD 60
ITLSKLYKLI EESCPQLANS VQIRIKLMAE GELKDMEQFF DDLSDSFSGT EPEVHKTSVV 120
GLFLRHMILA YSKLSFSQVF KLYTALQQYF QNGEKKTVED ADMDREDGEK QMEKEELDVS 180
VREEEVSCSG PLSQKQAEFF LSQQAALLKN DETKALTPAS LQKELNNLLK FNPDFAEAHY 240
LSYLNNLRVQ DVFSSTHSLL HYFDRLILTG AEGKSNGEEG YGRSLRYAAL NLAALHCRFG 300
HYQQAELALQ EAIRIAQESN DHVCLQHCLS WLYVLGQKRA DSYVLLEHSV KKAVHFGLPY 360
LASLGIQSLV QQRAFAGKTA NKLMDALKDS DLLHWKHSLS ELIDISIAQK TAIWRLYGRS 420
TMALQQAQML LSMNSLESLN AGVQQNNTES FAVALCHLAE LHAEQGCFAA AGEVLKHLKD 480
RFPPNSQHAQ LWMLCDQKIQ FDRAMNDGKF HLADSLVTGI TALNGIEGVY RKAVVLQAQN 540
QMTEAHKLLQ KLLTYCQKLK NTEMVISVLL SVAELYWRSS SPTIAMPVLL EALALSKEYR 600
LQYLASETVL NLAYAQLILG IPEQALTLLH MAIEPILADG AVLDKGRAMF LVSKCQVASA 660
ASYDPVKKAE ALEAAIQNLS EAKNYFAQVD CRERIRDVAY FQARLYHALG KTQERNHCAM 720
IFRQLHQELP AHGVPLINHL 740 |
Gene Ontology | GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB. GO:0051301; P:cell division; IEA:UniProtKB-KW. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |