CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028526
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Dedicator of cytokinesis protein 7 
Protein Synonyms/Alias
  
Gene Name
 Dock7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
549GELHEQFKRKTILTTacetylation[1, 2, 3, 4]
675SLIGPDQKEYQRELEubiquitination[5]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 727 AA 
Protein Sequence
GARQEMVRRS RGQLERSPSG SAFGSQENLR WRKDMTHWRQ NSEKLDKSRA EIEHEALIDG 60
NLATEANLII LDTLEIIVQT VSVTESKESI LGGVLKVLLQ SMACNQSAVY LQHCFATQRA 120
LVSKFPELLF EEETEQCADL CLRLLRHCSS SISTIRSHAS ASLYLLMRQN FEIGNNFARV 180
KMQVTMSLSS LVGTSQNFNE EFLRRSLKTI LTYAEEDLEL RETTFPDQVQ DLVFNLHMIL 240
SDTVKMKEHQ EDPEMLIDLM YRIAKGYQTS PDLRLTWLQN MAGKHSERSN HAEAAQCLVH 300
SAALVAEYLS MLEDRKYLPV GCVTFQNISS NVLEESAVSD DVVSPDEEGI CSGKYFTESG 360
LVGLLEQAAA SFSMAGMYEA VNEVYKVLIP IHEANRDAKK LSTIHGKLQE AFSKIVHQST 420
GWERMFGTYF RVGFYGTKFG DLDEQEFVYK EPAITKLAEI SHRLEGFYGE RFGEDVLEVI 480
KDSNPVDKCK LDPNKAYIQI TYVEPFFDTY EMKDRITYFD KNYNLRRFMY CTPFTLDGRA 540
HGELHEQFKR KTILTTSHAF PYIKTRVNVT HKEEIILTPI EVAIEDMQKK TQELAFATHQ 600
DPADPKMLQM VLQGSVGTTV NQGPLEVAQV FLSEIPGDPK LFRHHNKLRL CFKDFTKRCE 660
DALRKNKSLI GPDQKEYQRE LERNYHRLKE ALQPLINRKI PQLYKAVLPV TCHRDSFSRM 720
SLRKMEL 727 
Gene Ontology
 GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0043473; P:pigmentation; IMP:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 
Interpro
 IPR027357; DHR-2.
 IPR026791; DOCK.
 IPR010703; DOCK_C.
 IPR026798; DOCK_C_fam. 
Pfam
 PF06920; Ded_cyto 
SMART
  
PROSITE
 PS51651; DHR_2 
PRINTS