UniProt Accession

 ATP5H_RAT; P31399 

Genbank Protein ID

 D10021; D13120; BC059139; BC078846 

Genbank Nucleotide ID

 BAA00911.1; BAA02422.1; AAH59139.1; AAH78846.1 

Protein Name

 ATP synthase subunit d, mitochondrial 

Protein Synonyms/Alias

 ATPase subunit d 

Gene Name

 Atp5h 

Gene Synonyms/Alias

 Atp5jd 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
123	EKQLEKIKNMIPFDQ	acetylation	[1]
144	NEVFPETKLDKRKYP	acetylation	[1]
149	ETKLDKRKYPYWPHQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 63 63 N6-acetyllysine (By similarity).
 MOD_RES 78 78 N6-acetyllysine (By similarity).
 MOD_RES 85 85 N6-acetyllysine (By similarity).
 MOD_RES 95 95 N6-acetyllysine (By similarity).
 MOD_RES 99 99 N6-acetyllysine (By similarity).
 MOD_RES 117 117 N6-acetyllysine (By similarity).
 MOD_RES 149 149 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; CF(0); Complete proteome; Direct protein sequencing; Hydrogen ion transport; Ion transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0000276; C:mitochondrial proton-transporting ATP synthase complex, coupling factor F(o); IDA:RGD.
 GO:0015078; F:hydrogen ion transmembrane transporter activity; TAS:RGD.
 GO:0046034; P:ATP metabolic process; IDA:RGD.
 GO:0015986; P:ATP synthesis coupled proton transport; IEA:InterPro. 

Interpro

 IPR008689; ATPase_F0-cplx_dsu_mt. 

Pfam

 PF05873; Mt_ATP-synt_D 

SMART

  

PROSITE

  

PRINTS