UniProt Accession

 HTAI2_MOUSE; Q9Z2G9; Q810Y5; Q99KN6; Q9D5F8; Q9D804 

Genbank Protein ID

 AF061972; AY151050; AK008630; AK015389; AK144837; AC124775; CH466603; CH466603; CH466603; BC004083; BC017372 

Genbank Nucleotide ID

 AAC69617.1; AAN84531.1; BAB25792.1; BAB29825.1; BAE26091.1; EDL22975.1; EDL22976.1; EDL22977.1; AAH04083.1; AAH17372.1 

Protein Name

 Oxidoreductase HTATIP2 

Protein Synonyms/Alias

  

Gene Name

 Htatip2 

Gene Synonyms/Alias

 Cc3; Tip30 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
114	VDRDYVLKSAELAKA	ubiquitination	[1]
137	LSSRGADKSSSFLYL	ubiquitination	[1]
158	EAKVEELKFDRLSVF	acetylation	[2]
235	KAILHLGKDRDVPKL	acetylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Oxidoreductase required for tumor suppression. NAPDH- bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. 

Sequence Annotation

 NP_BIND 19 52 NADP (By similarity).
 ACT_SITE 143 143 Proton acceptor (By similarity).
 ACT_SITE 147 147 By similarity.
 BINDING 131 131 Substrate (By similarity).
 MOD_RES 45 45 Phosphoserine.  

Keyword

 3D-structure; Alternative splicing; Angiogenesis; Apoptosis; Complete proteome; Cytoplasm; Developmental protein; Differentiation; NADP; Nucleus; Oxidoreductase; Phosphoprotein; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 242 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005635; C:nuclear envelope; ISS:UniProtKB.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0051170; P:nuclear import; ISS:UniProtKB.
 GO:0045765; P:regulation of angiogenesis; ISS:UniProtKB.
 GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB. 

Interpro

 IPR016040; NAD(P)-bd_dom. 

Pfam

  

SMART

  

PROSITE

  

PRINTS