UniProt Accession

 GO45_HUMAN; Q9H2G9; O15298; Q5T531; Q5T533; Q9GZX4 

Genbank Protein ID

 U79751; AF288161; AF273875; AF288162; AF272386; AF272387; AF272388; AF273875; AF288162; AL356852; AL356852; CH471067; BC020716 

Genbank Nucleotide ID

 AAB63110.1; AAG37835.1; AAG37821.1; AAG37821.1; AAG37822.1; AAG37822.1; AAG37822.1; AAG37822.1; AAG37822.1; CAI19240.1; CAI19242.1; EAW90837.1; AAH20716.1 

Protein Name

 Golgin-45 

Protein Synonyms/Alias

 Basic leucine zipper nuclear factor 1; JEM-1; p45 basic leucine-zipper nuclear factor 

Gene Name

 BLZF1 

Gene Synonyms/Alias

 JEM1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
31	METEEPPKSVEVTSG	ubiquitination	[1]
67	PGVLQLGKMLTEKAM	ubiquitination	[1, 2]
72	LGKMLTEKAMEVKAV	ubiquitination	[1]
106	VKSLGHHKGEFLGQS	ubiquitination	[1]
144	ERRLLQDKEGLSNQL	ubiquitination	[2]
350	ILDPVTCKESSPDNP	ubiquitination	[3]
370	PTTLLATKKNIGRFH	ubiquitination	[1]
371	TTLLATKKNIGRFHP	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface. 

Sequence Annotation

 REGION 394 400 Essential for the interaction with
 MOTIF 18 22 Tankyrase-binding motif.
 MOD_RES 49 49 Phosphoserine.
 MOD_RES 348 348 Phosphothreonine.
 MOD_RES 353 353 Phosphoserine.  

Keyword

 ADP-ribosylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; ER-Golgi transport; Golgi apparatus; Nucleus; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 400 AA 

Protein Sequence

Gene Ontology

 GO:0005796; C:Golgi lumen; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; TAS:Reactome.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0007030; P:Golgi organization; IDA:MGI.
 GO:0043001; P:Golgi to plasma membrane protein transport; IDA:MGI.
 GO:0000278; P:mitotic cell cycle; TAS:Reactome.
 GO:0001558; P:regulation of cell growth; NAS:UniProtKB.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. 

Interpro

 IPR027095; Golgin-45.
 IPR013183; Hsk3_like. 

Pfam

 PF08227; DASH_Hsk3 

SMART

  

PROSITE

  

PRINTS