UniProt Accession

 RLUC_ECOLI; P0AA39; P23851 

Genbank Protein ID

 U00096; AP009048; M62747; M96791 

Genbank Nucleotide ID

 AAC74170.1; BAA35894.1; AAA23442.1; AAA23828.1 

Protein Name

 Ribosomal large subunit pseudouridine synthase C 

Protein Synonyms/Alias

 23S rRNA pseudouridine(955/2504/2580) synthase; rRNA pseudouridylate synthase C; rRNA-uridine isomerase C 

Gene Name

 rluC 

Gene Synonyms/Alias

 yceC; b1086; JW1072 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
35	TQLKGVPKSMIYRIL	acetylation	[1]
59	KRIKPEYKLEAGDEV	acetylation	[1]
174	LREKGMQKDYLALVR	acetylation	[1, 2]
189	GQWQSHVKSVQAPLL	acetylation	[1]
197	SVQAPLLKNILQSGE	acetylation	[1]
288	FLHAAALKFTHPGTG	acetylation	[1]
309	APMDEGLKRCLQKLR	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Responsible for synthesis of pseudouridine from uracil at positions 955, 2504 and 2580 in 23S ribosomal RNA. 

Sequence Annotation

 DOMAIN 20 83 S4 RNA-binding.
 ACT_SITE 144 144 By similarity.  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Isomerase; Reference proteome; RNA-binding; rRNA processing. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 319 AA 

Protein Sequence

Gene Ontology

 GO:0009982; F:pseudouridine synthase activity; IDA:EcoCyc.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IDA:EcoliWiki. 

Interpro

 IPR020103; PsdUridine_synth_cat_dom.
 IPR006225; PsdUridine_synth_RluC/D.
 IPR006224; PsdUridine_synth_RluC/D_CS.
 IPR006145; PsdUridine_synth_RsuA/RluD.
 IPR002942; S4_RNA-bd. 

Pfam

 PF00849; PseudoU_synth_2
 PF01479; S4 

SMART

 SM00363; S4 

PROSITE

 PS01129; PSI_RLU
 PS50889; S4 

PRINTS