CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-025492
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transporter 
Protein Synonyms/Alias
  
Gene Name
 Slc6a3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
598AYAITPEKDRQLVDRubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Membrane; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 619 AA 
Protein Sequence
MSKSKCSVGP MSSVVAPAKE PNAVGPREVE LILVKEQNGV QLTNSTLINP PQTPVEVQER 60
ETWSRKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV PYLLFMVIAG MPLFYMELAL 120
GQFNREGAAG VWKICPVLKG VGFTVILISF YVGFFYNVII AWALHYFFSS FTMDLPWIHC 180
NNTWNSPNCS DAHSSNSSDG LGLNDTFGTT PAAEYFERGV LHLHQSRGID DLGPPRWQLT 240
ACLVLVIVLL YFSLWKGVKT SGKVVWITAT MPYVVLTALL LRGVTLPGAM DGIRAYLSVD 300
FYRLCEASVW IDAATQVCFS LGVGFGVLIA FSSYNKFTNN CYRDAIITTS INSLTSFSSG 360
FVVFSFLGYM AQKHNVPIRD VATDGPGLIF IIYPEAIATL PLSSAWAAVF FLMLLTLGID 420
SAMGGMESVI TGLVDEFQLL HRHRELFTLG IVLATFLLSL FCVTNGGIYV FTLLDHFAAG 480
TSILFGVLIE AIGVAWFYGV QQFSDDIKQM TGQRPNLYWR LCWKLVSPCF LLYVVVVSIV 540
TFRPPHYGAY IFPDWANALG WIIATSSMAM VPIYATYKFC SLPGSFREKL AYAITPEKDR 600
QLVDRGEVRQ FTLRHWLLV 619 
Gene Ontology
 GO:0030424; C:axon; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0035240; F:dopamine binding; IDA:MGI.
 GO:0005329; F:dopamine transmembrane transporter activity; IMP:MGI.
 GO:0005330; F:dopamine:sodium symporter activity; IEA:InterPro.
 GO:0021984; P:adenohypophysis development; IMP:MGI.
 GO:0042416; P:dopamine biosynthetic process; IMP:MGI.
 GO:0042420; P:dopamine catabolic process; IMP:MGI.
 GO:0015872; P:dopamine transport; IMP:MGI.
 GO:0007595; P:lactation; IMP:MGI.
 GO:0007626; P:locomotory behavior; IMP:MGI.
 GO:0040018; P:positive regulation of multicellular organism growth; IMP:MGI.
 GO:0060134; P:prepulse inhibition; IMP:MGI.
 GO:0042053; P:regulation of dopamine metabolic process; IMP:MGI.
 GO:0042220; P:response to cocaine; IDA:MGI.
 GO:0007608; P:sensory perception of smell; IMP:MGI. 
Interpro
 IPR000175; Na/ntran_symport.
 IPR002436; Na/ntran_symport_dopamine. 
Pfam
 PF00209; SNF 
SMART
  
PROSITE
 PS00610; NA_NEUROTRAN_SYMP_1
 PS00754; NA_NEUROTRAN_SYMP_2
 PS50267; NA_NEUROTRAN_SYMP_3 
PRINTS
 PR01202; DOPTRANSPORT.
 PR00176; NANEUSMPORT.