| Tag | Content |
|---|
| CPLM ID | CPLM-014793 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Metal transporter CNNM4 |
Protein Synonyms/Alias | Ancient conserved domain-containing protein 4; mACDP4; Cyclin-M4 |
Gene Name | Cnnm4 |
Gene Synonyms/Alias | Acdp4; Kiaa1592 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 343 | EKLMEMLKVTEPYND | ubiquitination | [1] | | 436 | PDDCTPLKTITRFYN | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable metal transporter. The interaction with the metal ion chaperone COX11 suggests that it may play a role in sensory neuron functions (By similarity). May play a role in biomineralization and retinal function. |
Sequence Annotation | DOMAIN 182 355 DUF21.
DOMAIN 374 435 CBS 1.
DOMAIN 442 508 CBS 2.
MOD_RES 766 766 Phosphoserine.
CARBOHYD 119 119 N-linked (GlcNAc...) (Potential). |
Keyword | Biomineralization; CBS domain; Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Repeat; Sensory transduction; Transmembrane; Transmembrane helix; Transport; Vision. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 771 AA |
Protein Sequence | MAPGGGGGRR DGWPARGRLL LAALLLLWTR AASGQSSPQQ SVILGMRLAS CNKSCGMNPD 60
GIIFVSEGST VNLRLYGHSL GDISSNLISF TEVDDAEAVH NSTNCLELTK DLVVQRLVNV 120
SRGNTSGMLV VITKFLRRSE NMKLYALCTR PRADGPWTRW TDKDSLLFMV EEHGRFLPLW 180
LHILLVMVLL VLSGIFSGLN LGLMALDPME LRIVQNCGTE KERKYARKIE PIRRKGNYLL 240
CSLLLGNVLV NTSLTILLDN LIGSGIMAVA SSTIGIVIFG EILPQALCSR HGLAVGANTI 300
VLTKVFMLLT FPLSFPISKL LDFVLGQEIR TVYNREKLME MLKVTEPYND LVKEELNMIQ 360
GALELRTKTV EDIMTQLHDC FMIRSDAILD FNTMSEIMES GYTRIPVFED EQSNIVDILY 420
VKDLAFVDPD DCTPLKTITR FYNHPVHFVF HDTKLDAMLE EFKKGKSHLA IVQKVNNEGE 480
GDPFYEVLGL VTLEDVIEEI IKSEILDESD MYTDNRTRKR VSVKNKRDFS AFKDTDNELK 540
VKISPQLLLA AHRFLATEVP QFSPSLMSEK ILLRLLKYPD VIQELRFNEH NRYCVRHYLY 600
TRNKPADCFV LILQGKVEVE AGKENMKFET GAFSYYGTMA LSVAPPDRSP ALPTPLSRSA 660
SLSYPDRNTD LTSTSLAGSN QFGSCILGQY VSDFSVRALT DLQYIKITRQ QYQNGLMASR 720
MDNSPQPTFD GCATCSENFM ERPELPPVDE TTTLLNERNS LLHRASEEET I 771 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW. GO:0006811; P:ion transport; IEA:UniProtKB-KW. GO:0050896; P:response to stimulus; IEA:UniProtKB-KW. GO:0007601; P:visual perception; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |