CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036806
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Glucose-6-phosphate 1-dehydrogenase 
Protein Synonyms/Alias
  
Gene Name
 G6PD 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
82LTVADIRKQSEPFFKubiquitination[1]
89KQSEPFFKATPEEKLacetylation[2, 3]
89KQSEPFFKATPEEKLubiquitination[1, 4, 5]
95FKATPEEKLKLEDFFacetylation[5]
95FKATPEEKLKLEDFFubiquitination[1, 5]
97ATPEEKLKLEDFFARacetylation[3, 5]
97ATPEEKLKLEDFFARubiquitination[1, 4, 5, 6, 7]
172WNRIIVEKPFGRDLQacetylation[2, 3, 5]
172WNRIIVEKPFGRDLQubiquitination[1, 4, 5, 6]
206RIDHYLGKEMVQNLMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [7] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 320 AA 
Protein Sequence
MAEQVALSRT QVCGILREEL FQGDAFHQSD THIFIIMGAS GDLAKKKIYP TIWWLFRDGL 60
LPENTFIVGY ARSRLTVADI RKQSEPFFKA TPEEKLKLED FFARNSYVAG QYDDAASYQR 120
LNSHMNALHL GSQANRLFYL ALPPTVYEAV TKNIHESCMS QIRGWNRIIV EKPFGRDLQS 180
SDRLSNHISS LFREDQIYRI DHYLGKEMVQ NLMVLRFANR IFGPIWNRDN IACVILTFKE 240
PFGTEGRGGY FDEFGIIRDV MQNHLLQMLC LVAMEKPAST NSDDVRDEKV KVLKCISEVQ 300
ANNVVLGQYV GNPDGEGEAT 320 
Gene Ontology
 GO:0005813; C:centrosome; IDA:HPA.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:EC.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001282; G6P_DH.
 IPR019796; G6P_DH_AS.
 IPR022675; G6P_DH_C.
 IPR022674; G6P_DH_NAD-bd.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF02781; G6PD_C
 PF00479; G6PD_N 
SMART
  
PROSITE
 PS00069; G6P_DEHYDROGENASE 
PRINTS
 PR00079; G6PDHDRGNASE.