UniProt Accession

 TXN4B_HUMAN; Q9NX01; D3DWS6 

Genbank Protein ID

 AY566808; AK000518; CR457240; CH471166; CH471166; BC009646 

Genbank Nucleotide ID

 AAS68520.1; BAA91224.1; CAG33521.1; EAW59191.1; EAW59192.1; AAH09646.1 

Protein Name

 Thioredoxin-like protein 4B 

Protein Synonyms/Alias

 Dim1-like protein 

Gene Name

 TXNL4B 

Gene Synonyms/Alias

 DIM2; DLP 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
7	*MSFLLPKLTSKKEV	ubiquitination	[1, 2]
24	AIKSTAEKVLVLRFG	ubiquitination	[2]
47	QLDDILSKTSSDLSK	ubiquitination	[2]
127	YRGAMRGKLIVQSPI	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition. 

Sequence Annotation

  

Keyword

 3D-structure; Cell cycle; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 149 AA 

Protein Sequence

Gene Ontology

 GO:0005681; C:spliceosomal complex; IEA:InterPro.
 GO:0007067; P:mitosis; IEA:InterPro.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR004123; mRNA_splic_U5.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF02966; DIM1 

SMART

  

PROSITE

  

PRINTS