CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031304
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucose-6-phosphate isomerase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12TRDPQFQKLQQWYREubiquitination[1]
177IDGTHLAKTLAQLNPubiquitination[2]
235ALSTNTTKVKEFGIDubiquitination[1]
439LERLLPHKVFEGNRPubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Gluconeogenesis; Glycolysis; Isomerase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 531 AA 
Protein Sequence
MAALTRDPQF QKLQQWYREH RSELNLRRLF DANKDRFNHF SLTLNTNHGH ILVDYSKNLV 60
TEDVMRMFNG EKINYTEGRA VLHVALRNRS NTPILVDGKD VMPEVNKVLD KMKSFCQRVR 120
SGDWKGYTGK TITDVINIGI GGSDLGPLMV TEALKPYSSG GPRVWYVSNI DGTHLAKTLA 180
QLNPESSLFI IASKTFTTQE TITNAETAKE WFLQAAKDPS AVAKHFVALS TNTTKVKEFG 240
IDPQNMFEFW DWVGGRYSLW SAIGLSIALL SGAHWMDQHF RTTPLGKNAP VLLALLGVWY 300
INCFGCETHA MLPYDQYLHR FAAYFQQGDM ESNGKYITKS GTRVDHQTGP IVWGEPGTNG 360
QHAFYQLIHQ GTKMIPCDFL IPVQTQHPIR KGLHHKILLA NFLAQTEALM RGKSTEEARK 420
ELQAAGKSPE DLERLLPHKV FEGNRPTNSI VFTKLTPFML GALVAMYEHK IFVQGIIWDI 480
NSFDQWGVEL GKQLAKKIEP ELDGSAQVTS HDASTNGLIN FIKQQREARV Q 531 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:EC.
 GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway. 
Interpro
 IPR001672; G6P_Isomerase.
 IPR023096; G6P_Isomerase_C.
 IPR018189; Phosphoglucose_isomerase_CS. 
Pfam
 PF00342; PGI 
SMART
  
PROSITE
 PS00765; P_GLUCOSE_ISOMERASE_1
 PS00174; P_GLUCOSE_ISOMERASE_2
 PS51463; P_GLUCOSE_ISOMERASE_3 
PRINTS
 PR00662; G6PISOMERASE.