UniProt Accession

 LPP_ECOLI; P69776; P02937; Q53272 

Genbank Protein ID

 V00302; X68953; U00096; AP009048; S42225 

Genbank Nucleotide ID

 CAA23580.1; CAA48767.1; AAC74747.1; BAA16044.1; AAB22836.1 

Protein Name

 Major outer membrane lipoprotein Lpp 

Protein Synonyms/Alias

 Braun lipoprotein; Murein-lipoprotein 

Gene Name

 lpp 

Gene Synonyms/Alias

 mlpA; mulI; b1677; JW1667 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
75	RLDNMATKYRK****	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Interacts with the peptidoglycan both covalently and noncovalently. This interaction contributes to the maintenance of the structural and functional integrity of the cell envelope. 

Sequence Annotation

 REPEAT 24 34
 REPEAT 38 48
 MOD_RES 1 1 N-formylmethionine.
 MOD_RES 78 78 N6-murein peptidoglycan lysine.
 LIPID 21 21 N-palmitoyl cysteine.
 LIPID 21 21 S-diacylglycerol cysteine.  

Keyword

 3D-structure; Cell membrane; Cell outer membrane; Complete proteome; Direct protein sequencing; Formylation; Lipoprotein; Membrane; Palmitate; Peptidoglycan-anchor; Reference proteome; Repeat; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 78 AA 

Protein Sequence

Gene Ontology

 GO:0045203; C:integral to cell outer membrane; IDA:EcoCyc.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
 GO:0008289; F:lipid binding; NAS:UniProtKB.
 GO:0042834; F:peptidoglycan binding; TAS:UniProtKB.
 GO:0030258; P:lipid modification; IMP:UniProtKB. 

Interpro

 IPR006817; LPP.
 IPR016367; Murein-lipoprotein. 

Pfam

 PF04728; LPP 

SMART

  

PROSITE

 PS51257; PROKAR_LIPOPROTEIN 

PRINTS