CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024155
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 23 member 1 
Protein Synonyms/Alias
 Na(+)/L-ascorbic acid transporter 1; Sodium-dependent vitamin C transporter 1; Yolk sac permease-like molecule 3 
Gene Name
 Slc23a1 
Gene Synonyms/Alias
 Svct1; Yspl3 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
11PEDPGSPKQHEVVDSubiquitination[1]
35APLPTEPKFDMLYKIubiquitination[1]
604ETGSVCTKV******ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (By similarity). 
Sequence Annotation
 MOD_RES 603 603 Phosphothreonine.
 CARBOHYD 145 145 N-linked (GlcNAc...) (Potential).
 CARBOHYD 151 151 N-linked (GlcNAc...) (Potential).  
Keyword
 Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 605 AA 
Protein Sequence
MKTPEDPGSP KQHEVVDSAG TSTRDRQAPL PTEPKFDMLY KIEDVPPWYL CILLGFQHYL 60
TCFSGTIAVP FLLAEALCVG RDQHMVSQLI GTIFTCVGIT TLIQTTVGIR LPLFQASAFA 120
FLVPAKSILA LERWKCPSEE EIYGNWSMPL NTSHIWHPRI REVQGAIMVS SMVEVVIGLM 180
GLPGALLSYI GPLTVTPTVS LIGLSVFQAA GDRAGSHWGI SACSILLIVL FSQYLRNLTF 240
LLPVYRWGKG LTLFRVQIFK MFPIVLAIMT VWLLCYVLTL TDVLPADPTV YGFQARTDAR 300
GDIMAISPWI RIPYPCQWGL PTVTVAAVLG MFSATLAGII ESIGDYYACA RLAGAPPPPV 360
HAINRGIFTE GICCIIAGLL GTGNGSTSSS PNIGVLGITK VGSRRVVQYG AGIMLILGAI 420
GKFTALFASL PDPILGGMFC TLFGMITAVG LSNLQFVDMN SSRNLFVLGF SMFFGLTLPN 480
YLDSNPGAIN TGIPEVDQIL TVLLTTEMFV GGCLAFILDN TVPGSPEERG LIQWKAGAHA 540
NSETSASLKS YDFPFGMGMV KRTTFFRYIP ICPVFRGFSK KTQNQPPVLE DTPDNIETGS 600
VCTKV 605 
Gene Ontology
 GO:0016324; C:apical plasma membrane; ISS:UniProtKB.
 GO:0009925; C:basal plasma membrane; IDA:UniProtKB.
 GO:0005903; C:brush border; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0043229; C:intracellular organelle; ISS:UniProtKB.
 GO:0033300; F:dehydroascorbic acid transporter activity; ISS:UniProtKB.
 GO:0008520; F:L-ascorbate:sodium symporter activity; IEA:Compara.
 GO:0070890; F:sodium-dependent L-ascorbate transmembrane transporter activity; ISS:UniProtKB.
 GO:0007420; P:brain development; IMP:UniProtKB.
 GO:0030324; P:lung development; IMP:UniProtKB.
 GO:0009636; P:response to toxic substance; ISS:UniProtKB.
 GO:0070904; P:transepithelial L-ascorbic acid transport; ISS:UniProtKB. 
Interpro
 IPR006043; Xant/urac/vitC. 
Pfam
 PF00860; Xan_ur_permease 
SMART
  
PROSITE
  
PRINTS