CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040641
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 
Protein Synonyms/Alias
  
Gene Name
 ATP2A2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18SVQRIKAKDIVPGDIubiquitination[1]
33VEIAVGDKVPADIRLubiquitination[1]
44DIRLTSIKSTTLRVDubiquitination[2, 3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 57 AA 
Protein Sequence
MGKVYRQDRK SVQRIKAKDI VPGDIVEIAV GDKVPADIRL TSIKSTTLRV DQSILTG 57 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005388; F:calcium-transporting ATPase activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0006984; P:ER-nucleus signaling pathway; IEA:Compara.
 GO:0045822; P:negative regulation of heart contraction; IEA:Compara.
 GO:0002026; P:regulation of the force of heart contraction; IEA:Compara. 
Interpro
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase. 
Pfam
 PF00122; E1-E2_ATPase 
SMART
  
PROSITE
  
PRINTS