CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017229
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 General transcription factor 3C polypeptide 1 
Protein Synonyms/Alias
 TF3C-alpha; TFIIIC box B-binding subunit; Transcription factor IIIC 220 kDa subunit; TFIIIC 220 kDa subunit; TFIIIC220; Transcription factor IIIC subunit alpha 
Gene Name
 Gtf3c1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
218YHRKILNKNGLITMQubiquitination[1]
724SSTANRVKVPPAPAPubiquitination[1]
1123SSFYAHLKRNWVWTSubiquitination[1]
1670VVNSCQVKFRLRNTPubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. Binds to the box B promoter element (By similarity). 
Sequence Annotation
 MOD_RES 667 667 Phosphoserine (By similarity).
 MOD_RES 1063 1063 Phosphoserine (By similarity).
 MOD_RES 1854 1854 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2101 AA 
Protein Sequence
MDALESLLDE VALEGLDGLC LPALWSRLES RSPAFPLPLE PYTQEFLWRA LATHPGISFY 60
EEPRERPDLQ LQDRYEEIDL ETGILESRRD PVTLEDVYPI HMILENKDGI QGSCRYFKER 120
KDITSSIRSK CLQPRCTMVE AFSRWGKKLI IVASQDMRYR ALIGLEGDPD LKLPDFSYCI 180
LERLGRSRWQ GELQRDLHTT AFKVDAGKLH YHRKILNKNG LITMQSHVIR LPTGAQQHSI 240
LLLLNRFHVD RRSKYDILME KLSMMLSTRS NQIETLGKLR EELGLCERTF KRLYQYMLNA 300
GLAKVVSLPL QEIHPECGPC KTKKGTDVMV RCLKLLKEFK RKMEDDHDDD DDEEVISKGV 360
PPVDIVFERD MLTQTYELIE RRGTKGISQA EIRVAMNVGK LEARMLCRLL QRFKVVKGFM 420
EDEGRQRTTK YISCVFAEES DLSRQYAREK ARGELLTTVS LASVQDESLM PEGEEAFLSD 480
SESEEESSCS GGKRRGRGSR GHARASGDAG SGSRPHHSTP AKGGWKVLNL HPLKKPKAAA 540
EERSRRSSAC RDGLDTSSSS ELNAPFDPHS MDSHSGDIAV IEEVRLDNPK EGGGSQKGGR 600
HGSSQDKPHK TYRLLKRRNL IIEAVTNLRL IESLFTIQKM IMDQEKQEGV STKCCKKSII 660
RLVRNLSEEG LLRLYRTTVI QDGIKKKVDL VVHPSMDQND PLVRSAIEQV RFRISNSSTA 720
NRVKVPPAPA PQEEAEEENQ EPEVPSRSAN SDPNTSSKPE STRVKKTDEK MGITPLKNYK 780
PVIVPGLGRS IGFLPKMPRL KAMHLFLWYL VYGHPAGHTG EQPALHSERK TGKQESSRPG 840
AQPSSGDDWD TSEAKNNTES SSWESEMELS TEIVYVDEIS WMRYVPPIPI HRDFGFGWAL 900
VSDILLCLPL SIFVQLVQVS YKVDNLEDFL NDPLKKHTLI RFLPRHIRQQ LLYKRRYIFS 960
VVENLQRLCY MGLLQFGPTE KFQDKDQVFV FLKKNAVIVD TTICDPHYNL AHSSRPFERR 1020
LYVLDSMQDV ECYWFDLQCI CLNTPLGVVR CPCAQKICPD PGSDPEGSLR KEQESAMDKH 1080
NLERKCAMLE YTTGSREVVD EGLVPGDGLG AAGLDSSFYA HLKRNWVWTS YIINKARKNN 1140
TSENGLTGRL QTFLSKRPMP LGSGGSGRLP LWSEGRADAE LCADKEEQFE LDREPTPGRN 1200
RKVRGGKSQK RKRLKKEPIR KTKRRRRGEH PEAKSKKLRY QDEADQNALR MMTRLRVSWS 1260
MQEDGLLMLC RIASNVLNTK VKGPFVTWQV VRDILHATFE ESLDKTSHSV GRRARYIVKN 1320
PQAFMNYKVC LAEVYQDKAL VGDFMSRKGN YEDPKVCAKE FKEFVEKLKE KFSSGLRNPN 1380
LEIPNTLQEL FAKYRVLAIG DEKDRVRKED ELNSVEDIHF LVLQNLIQST LSLSNSQSNS 1440
CQSFQIFRLY REFREPVLVR AFMECQKRSL VNRRRVSHSQ GPKKNRAVPF VPMSYQLSQS 1500
YYKLFTWRFP TTICTESFQF YDRLRTNGML DQPDHFSFKD LDSSDPSNDL VAFSLDSPGG 1560
HCVTALALFS LGLLSVDVRI PEQIVVVDSS MVESEVMKSL GKDGGLDDDE EEEDLDEGSG 1620
TKRQGVEVKA HQASHTKYLL MRGYYTVPGM VSTRNLNPND SIVVNSCQVK FRLRNTPAST 1680
QLGPTGFTAT PLEELQAGLS CLPASFTSLV DPQLRTHCPE EFAHQMAQSG YSPEDVAASL 1740
EILQAVAAAD CFGIDKEKLS RQFSALEKIA DRRTRTFLDY IQDLLEQEQV MEVGGNTVRL 1800
VTMASAQPWL LHSMRLRDME VDTKASGDDS QSRLPEGPSI EDHTSEGAAV PPVSSHSTKK 1860
RPHCPETDAE EATRLPAKKP TLQDVRVAAS PRPGAEEQAE AQAPAQLAAP EDADAGGPRQ 1920
ENQENVGVSG LEQLGCEFQL PEGSEDPRGL TESNMAQAAW ESGCERVCFV GRPWRGVDGH 1980
LNMPVCKGML EAVLYHIMSR PGVPESCLLQ YYQGVLQPVA VLELLRGLES LGCIQKRTLR 2040
KPASVSLFSR PVVEGLGQAS EAEALSCHES TVTFYEPTLD CTIRLGRVFP HDINWNKWIH 2100
L 2101 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0030529; C:ribonucleoprotein complex; IDA:MGI.
 GO:0000127; C:transcription factor TFIIIC complex; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007309; TFIIIC_Bblock-bd. 
Pfam
 PF04182; B-block_TFIIIC 
SMART
  
PROSITE
  
PRINTS