CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043377
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Prefoldin subunit 5 
Protein Synonyms/Alias
  
Gene Name
 PFDN5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
38QLKVVQTKYVEAKDCacetylation[1]
43QTKYVEAKDCLNVLNacetylation[1, 2]
43QTKYVEAKDCLNVLNubiquitination[1, 3]
92GTGYYVEKTAEDAKDubiquitination[4, 5]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 152 AA 
Protein Sequence
XNITELNLPQ LEMLKNQLDQ EVEFLSTSIA QLKVVQTKYV EAKDCLNVLN KSNEDGISLC 60
RPGWSAMMYV PGKLHDVEHV LIDVGTGYYV EKTAEDAKDF FKRKIDFLTK QMEKIQPALQ 120
EKHAMKQAVM EMMSQKIQQL TALGAAQATA KA 152 
Gene Ontology
 GO:0016272; C:prefoldin complex; IEA:InterPro.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR011599; PFD_alpha.
 IPR027236; PFDN5.
 IPR009053; Prefoldin.
 IPR004127; Prefoldin_subunit. 
Pfam
 PF02996; Prefoldin 
SMART
  
PROSITE
  
PRINTS