UniProt Accession

 AK1CD_MOUSE; Q8VC28; Q9D7R9; Q9R0M9 

Genbank Protein ID

 AB027125; AK008949; BC021937 

Genbank Nucleotide ID

 BAA86850.1; BAB25986.1; AAH21937.1 

Protein Name

 Aldo-keto reductase family 1 member C13 

Protein Synonyms/Alias

  

Gene Name

 Akr1c13 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
161	CKDAGLVKSIGVSNF	ubiquitination	[1]
225	ALGTQRYKEWVDQNS	ubiquitination	[1]
246	PVLCDVAKKNKRSPA	ubiquitination	[1]
273	VPLAQSFKENEMREN	acetylation	[2]
273	VPLAQSFKENEMREN	ubiquitination	[1]
301	KTLDGLNKNFRYLPA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758] 

Functional Description

  

Sequence Annotation

 NP_BIND 13 22 NADP (Potential).
 NP_BIND 217 280 NADP (By similarity).
 ACT_SITE 55 55 Proton donor (By similarity).
 BINDING 117 117 Substrate (By similarity).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; NAD; NADP; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0004033; F:aldo-keto reductase (NADP) activity; ISS:MGI.
 GO:0006805; P:xenobiotic metabolic process; TAS:MGI. 

Interpro

 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 

Pfam

 PF00248; Aldo_ket_red 

SMART

  

PROSITE

 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 

PRINTS

 PR00069; ALDKETRDTASE.