CPLM 1.0 - Compendium of Protein Lysine Modification
Tag
Content
CPLM ID
CPLM-035865
UniProt Accession
D4IB68_ERWAE
;
D4IB68
Genbank Protein ID
FN666575
Genbank Nucleotide ID
CBJ46195.1
Protein Name
Isocitrate dehydrogenase [NADP]
Protein Synonyms/Alias
Gene Name
icdA
Gene Synonyms/Alias
EAM_1520
Created Date
July 27, 2013
Organism
Erwinia amylovora (strain ATCC 49946 / CCPPB 0273 / Ea273 / 27-3)
NCBI Taxa ID
716540
Lysine Modification
Position
Peptide
Type
References
235
VHKGNIM
K
FTEGAFK
acetylation
[1]
242
KFTEGAF
K
DWGYQLA
acetylation
[1]
344
ATHGTAP
K
YAGQDKV
acetylation
[1]
350
PKYAGQD
K
VNPGSVI
acetylation
[1]
Reference
[1] Differential lysine acetylation profiles of Erwinia amylovora strains revealed by proteomics.
Wu X, Vellaichamy A, Wang D, Zamdborg L, Kelleher NL, Huber SC, Zhao Y.
J Proteomics. 2013 Feb 21;79:60-71. [
PMID: 23234799
]
Functional Description
Sequence Annotation
Keyword
Complete proteome; Glyoxylate bypass; Manganese; Metal-binding; NADP; Oxidoreductase; Tricarboxylic acid cycle.
Sequence Source
UniProt (SWISSPROT/TrEMBL); GenBank; EMBL
Protein Length
416 AA
Protein Sequence
MESKVVVPAE GQKITLDQGK LNVPDNPIIP FIEGDGIGVD VSPVMIKVVD AAVQKAYGGE 60
RKISWMEIYT GEKSVALYGQ DVWLPEETLD LIKEYRVAIK GPLTTPVGGG IRSLNVALRQ 120
QLDLYICLRP VRYYTGTPSP VKRPQDTDMV IFRENAEDIY AGIEWKAGTP EADKVIKFLR 180
DEMGVKKIRF PEQCGIGVKP CSEAGTKRLV RAAIEYAIDN DRDSVTLVHK GNIMKFTEGA 240
FKDWGYQLAK DEFGGEPIDG GPWLTISNPN TGKEIVIKDV IADAFLQQIL LRPAEYDVIA 300
CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK VNPGSVILSA 360
EMMLRHMGWF EAADLIVKGM EGAIAAKTVT YDFERLMDGA KLLKSSEFGD AMITHM 416
Gene Ontology
GO:0004450
; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.
GO:0000287
; F:magnesium ion binding; IEA:InterPro.
GO:0051287
; F:NAD binding; IEA:InterPro.
GO:0006097
; P:glyoxylate cycle; IEA:UniProtKB-KW.
GO:0006099
; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
Interpro
IPR019818
; IsoCit/isopropylmalate_DH_CS.
IPR001804
; Isocitrate/isopropylmalate_DH.
IPR004439
; Isocitrate_DH_NADP_dimer_prok.
IPR024084
; IsoPropMal-DH-like_dom.
Pfam
PF00180
; Iso_dh
SMART
PROSITE
PS00470
; IDH_IMDH
PRINTS