| Tag | Content |
|---|
| CPLM ID | CPLM-022370 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier family 2, facilitated glucose transporter member 8 |
Protein Synonyms/Alias | Glucose transporter type 8; GLUT-8; Glucose transporter type X1 |
Gene Name | SLC2A8 |
Gene Synonyms/Alias | GLUT8; GLUTX1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 465 | CVPETKGKTLEQITA | ubiquitination | [1] |
|
Reference | [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C. Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [ PMID: 21890473] |
Functional Description | Insulin-regulated facilitative glucose transporter. Binds cytochalasin B in a glucose-inhibitable manner. Seems to be a dual-specific sugar transporter as it is inhibitable by fructose (By similarity). |
Sequence Annotation | MOTIF 12 13 Dileucine internalization motif
CARBOHYD 349 349 N-linked (GlcNAc...) (By similarity). |
Keyword | Cell membrane; Complete proteome; Cytoplasmic vesicle; Glycoprotein; Membrane; Polymorphism; Reference proteome; Sugar transport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 477 AA |
Protein Sequence | MTPEDPEETQ PLLGPPGGSA PRGRRVFLAA FAAALGPLSF GFALGYSSPA IPSLQRAAPP 60
APRLDDAAAS WFGAVVTLGA AAGGVLGGWL VDRAGRKLSL LLCSVPFVAG FAVITAAQDV 120
WMLLGGRLLT GLACGVASLV APVYISEIAY PAVRGLLGSC VQLMVVVGIL LAYLAGWVLE 180
WRWLAVLGCV PPSLMLLLMC FMPETPRFLL TQHRRQEAMA ALRFLWGSEQ GWEDPPIGAE 240
QSFHLALLRQ PGIYKPFIIG VSLMAFQQLS GVNAVMFYAE TIFEEAKFKD SSLASVVVGV 300
IQVLFTAVAA LIMDRAGRRL LLVLSGVVMV FSTSAFGAYF KLTQGGPGNS SHVAISAPVS 360
AQPVDASVGL AWLAVGSMCL FIAGFAVGWG PIPWLLMSEI FPLHVKGVAT GICVLTNWLM 420
AFLVTKEFSS LMEVLRPYGA FWLASAFCIF SVLFTLFCVP ETKGKTLEQI TAHFEGR 477 |
Gene Ontology | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0005887; C:integral to plasma membrane; TAS:ProtInc. GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA. GO:0008021; C:synaptic vesicle; IEA:Compara. GO:0005536; F:glucose binding; IEA:Compara. GO:0005355; F:glucose transmembrane transporter activity; TAS:ProtInc. GO:0005975; P:carbohydrate metabolic process; TAS:ProtInc. GO:0008286; P:insulin receptor signaling pathway; IEA:Compara. GO:0007141; P:male meiosis I; IEA:Compara. GO:0001666; P:response to hypoxia; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |