UniProt Accession

 B7WNT5_HUMAN; B7WNT5 

Genbank Protein ID

 AC008608; AC011336; CH471062 

Genbank Nucleotide ID

 EAW62279.1 

Protein Name

 Transcription factor 7 

Protein Synonyms/Alias

 Transcription factor 7 (T-cell specific, HMG-box), isoform CRA_c 

Gene Name

 TCF7 

Gene Synonyms/Alias

 hCG_16589 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
36	EGEEQDDKSRDSAAG	ubiquitination	[1]
52	ERDLAELKSSLVNES	ubiquitination	[1, 2, 3]
98	AQRLFPDKLPEPLED	ubiquitination	[1, 3]
108	EPLEDGLKAPECTSG	ubiquitination	[1, 3]
181	APADISQKQVHRPLQ	ubiquitination	[3]
253	QPFDRNLKTQAESKA	ubiquitination	[1, 3]
259	LKTQAESKAEKEAKK	ubiquitination	[1]
271	AKKPTIKKPLNAFML	ubiquitination	[1, 2]
281	NAFMLYMKEMRAKVI	ubiquitination	[1]
286	YMKEMRAKVIAECTL	ubiquitination	[1, 3]
294	VIAECTLKESAAINQ	ubiquitination	[1, 3]
317	LSREEQAKYYELARK	ubiquitination	[1, 2, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 481 AA 

Protein Sequence

Gene Ontology

 GO:0016055; P:Wnt receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR027397; Catenin_binding_dom.
 IPR013558; CTNNB1-bd_N.
 IPR009071; HMG_box_dom.
 IPR024940; TCF/LEF. 

Pfam

 PF08347; CTNNB1_binding
 PF00505; HMG_box 

SMART

 SM00398; HMG 

PROSITE

 PS50118; HMG_BOX_2 

PRINTS