| Tag | Content |
|---|
| CPLM ID | CPLM-001447 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Coatomer subunit epsilon |
Protein Synonyms/Alias | Epsilon-coat protein; Epsilon-COP |
Gene Name | Cope |
Gene Synonyms/Alias | Cope1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 265 | VLSQHLGKPPEVTNR | ubiquitination | [1] | | 278 | NRYLSQLKDAHRAHP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). |
Sequence Annotation | |
Keyword | Complete proteome; Cytoplasm; Cytoplasmic vesicle; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 308 AA |
Protein Sequence | MAPPVPGAVS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKLSSPEREV ERDVFLYRAY 60
LAQRKYGVVL DEIKPSSAPE LQAVRMFAEY LASENQRDSI VLELDREMSR SVDVTNTTFL 120
LMAASIYFHD QNPDAALRTL HQGDGLECMA MTIQILLKLD RLDLARKELK KMQDQDEDAT 180
LTQLATAWVN LAVGGEKLQE AYYIFQELAD KCSPTLLLLN GQAACHSAQG RWETAEGVLQ 240
EALDKDSGHP ETLINLIVLS QHLGKPPEVT NRYLSQLKDA HRAHPFIKEY QAKENDFDRL 300
AMQYAPSA 308 |
Gene Ontology | GO:0030126; C:COPI vesicle coat; IEA:InterPro. GO:0030137; C:COPI-coated vesicle; IDA:MGI. GO:0005198; F:structural molecule activity; IEA:InterPro. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |