CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033074
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine/tyrosine-interacting-like protein 1 
Protein Synonyms/Alias
  
Gene Name
 STYXL1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21NILNQATKLSRLTDPubiquitination[1]
39CLLDVRSKWEYDESHubiquitination[1, 2, 3]
128HHPVYILKGGYERFSubiquitination[2, 3, 4]
145YHFLRTQKIIWMPQEubiquitination[2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 282 AA 
Protein Sequence
MPGLLLCEPT ELYNILNQAT KLSRLTDPNY LCLLDVRSKW EYDESHVITA LRVKKKNNEY 60
LLPESVDLEC VKYCVVYDNN SSTLEILLKD DDDDSDSDGD GKDLVPQAAI EYGRILTRLT 120
HHPVYILKGG YERFSGTYHF LRTQKIIWMP QELDAFQPYP IEIVPGKVFV GNFSQACDPK 180
IQKDLKIKAH VNVSMDTGPF FAGDADKLLH IRIEDSPEAQ ILPFLRHMCH FIEIHHHLGS 240
VILIFSTQGI SRSCAAIIAY LMHSNEQTLQ TESRSVTQAG VQ 282 
Gene Ontology
 GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
 GO:0006470; P:protein dephosphorylation; IEA:InterPro. 
Interpro
 IPR000340; Dual-sp_phosphatase_cat-dom.
 IPR020422; Dual-sp_phosphatase_subgr_cat.
 IPR024950; DUSP.
 IPR001763; Rhodanese-like_dom. 
Pfam
 PF00782; DSPc
 PF00581; Rhodanese 
SMART
 SM00450; RHOD 
PROSITE
 PS50054; TYR_PHOSPHATASE_DUAL 
PRINTS