UniProt Accession

 THIO_ECOLI; P0AA25; P00274; P76750; Q2M889; Q47674; Q8XAT2 

Genbank Protein ID

 M26133; K02845; M10424; M54881; M12779; M87049; U00096; AP009048 

Genbank Nucleotide ID

 AAA24693.1; AAA24534.1; AAA24533.1; AAA24696.1; AAA24694.1; AAA67582.1; AAC76786.2; BAE77517.1 

Protein Name

 Thioredoxin-1 

Protein Synonyms/Alias

 Trx-1 

Gene Name

 trxA 

Gene Synonyms/Alias

 fipA; tsnC; b3781; JW5856 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
4	****MSDKIIHLTDD	acetylation	[1]
53	IADEYQGKLTVAKLN	acetylation	[1]
58	QGKLTVAKLNIDQNP	acetylation	[1, 2]
70	QNPGTAPKYGIRGIP	acetylation	[1, 3]
83	IPTLLLFKNGEVAAT	acetylation	[1]
91	NGEVAATKVGALSKG	acetylation	[1]
97	TKVGALSKGQLKEFL	acetylation	[1]
101	ALSKGQLKEFLDANL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111]
 [3] Lysine acetylation is a highly abundant and evolutionarily conserved modification in Escherichia coli.
 Zhang J, Sprung R, Pei J, Tan X, Kim S, Zhu H, Liu CF, Grishin NV, Zhao Y.
 Mol Cell Proteomics. 2009 Feb;8(2):215-25. [PMID: 18723842] 

Functional Description

 Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. 

Sequence Annotation

 DOMAIN 2 109 Thioredoxin.
 ACT_SITE 33 33 Nucleophile.
 ACT_SITE 36 36 Nucleophile.
 MOD_RES 70 70 N6-acetyllysine.
 DISULFID 33 36 Redox-active.  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Disulfide bond; Electron transport; Host-virus interaction; Redox-active center; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 109 AA 

Protein Sequence

Gene Ontology

 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0015035; F:protein disulfide oxidoreductase activity; IDA:EcoCyc.
 GO:0045454; P:cell redox homeostasis; IMP:EcoCyc.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW.
 GO:0006662; P:glycerol ether metabolic process; IEA:InterPro.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 

Interpro

 IPR005746; Thioredoxin.
 IPR012336; Thioredoxin-like_fold.
 IPR017937; Thioredoxin_CS.
 IPR013766; Thioredoxin_domain. 

Pfam

 PF00085; Thioredoxin 

SMART

  

PROSITE

 PS00194; THIOREDOXIN_1
 PS51352; THIOREDOXIN_2 

PRINTS

 PR00421; THIOREDOXIN.