UniProt Accession

 RIB3_YEAST; Q99258; D6VTB0 

Genbank Protein ID

 Z21619; U33050; AY557810; BK006938 

Genbank Nucleotide ID

 CAA79743.1; AAB64927.1; AAS56136.1; DAA12320.1 

Protein Name

 3,4-dihydroxy-2-butanone 4-phosphate synthase 

Protein Synonyms/Alias

 DHBP synthase 

Gene Name

 RIB3 

Gene Synonyms/Alias

 YDR487C; D8035.30 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
190	NDCQAFGKKHGIPLI	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity). 

Sequence Annotation

 REGION 26 27 Substrate binding (By similarity).
 REGION 145 149 Substrate binding (By similarity).
 METAL 27 27 Magnesium or manganese 1 (By similarity).
 METAL 27 27 Magnesium or manganese 2 (By similarity).
 METAL 148 148 Magnesium or manganese 2 (By similarity).
 BINDING 31 31 Substrate (By similarity).
 BINDING 169 169 Substrate (By similarity).
 MOD_RES 3 3 Phosphothreonine.  

Keyword

 Complete proteome; Lyase; Magnesium; Manganese; Metal-binding; Phosphoprotein; Reference proteome; Riboflavin biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 208 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005758; C:mitochondrial intermembrane space; IDA:SGD.
 GO:0008686; F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity; IMP:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0009060; P:aerobic respiration; IMP:SGD.
 GO:0009231; P:riboflavin biosynthetic process; IMP:SGD. 

Interpro

 IPR017945; DHBP_synth_RibB-like_a/b_dom.
 IPR000422; DHBP_synthase_RibB. 

Pfam

 PF00926; DHBP_synthase 

SMART

  

PROSITE

  

PRINTS