CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037437
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform 
Protein Synonyms/Alias
  
Gene Name
 PPP2R5D 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
74SGGPQIVKKERRQSSubiquitination[1]
88SSRFNLSKNRELQKLubiquitination[1]
113REELFIQKLRQCCVLubiquitination[1, 2]
132SDPLSDLKFKEVKRAubiquitination[1]
224DFQPNIAKKYIDQKFubiquitination[1, 2, 3, 4]
326LLPLHKVKSLSVYHPubiquitination[1]
359PVIVGLLKFWPKTHSubiquitination[1, 3, 5]
401PLFRQLAKCVSSPHFubiquitination[1]
481DDCTQQYKAEKQKGRubiquitination[1]
492QKGRFRMKEREEMWQubiquitination[1]
500EREEMWQKIEELARLubiquitination[1, 2, 4]
540AEDIQLLKRTVETEAubiquitination[1, 2, 3, 6]
564EKVLLRRKSELPQDVubiquitination[1]
575PQDVYTIKALEAHKRubiquitination[5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 594 AA 
Protein Sequence
MPYKLKKEKE PPKVAKCTAK PSSSGKDGGG ENTEEPQPQA QSQPPSSNKR PSNSTPPPTQ 60
LSKIKYSGGP QIVKKERRQS SSRFNLSKNR ELQKLPALKD SPTQEREELF IQKLRQCCVL 120
FDFVSDPLSD LKFKEVKRAG LNEMVEYITH SRDVVTEAIY PEAVTMFSVN LFRTLPPSSN 180
PTGAEFDPEE DEPTLEAAWP HLQLVYEFFL RFLESPDFQP NIAKKYIDQK FVLALLDLFD 240
SEDPRERDFL KTILHRIYGK FLGLRAYIRR QINHIFYRFI YETEHHNGIA ELLEILGSII 300
NGFALPLKEE HKMFLIRVLL PLHKVKSLSV YHPQLAYCVV QFLEKESSLT EPVIVGLLKF 360
WPKTHSPKEV MFLNELEEIL DVIEPSEFSK VMEPLFRQLA KCVSSPHFQV AERALYYWNN 420
EYIMSLISDN AARVLPIMFP ALYRNSKSHW NKTIHGLIYN ALKLFMEMNQ KLFDDCTQQY 480
KAEKQKGRFR MKEREEMWQK IEELARLNPQ YPMFRAPPPL PPVYSMETET PTAEDIQLLK 540
RTVETEAVQM LKDIKKEKVL LRRKSELPQD VYTIKALEAH KRAEEFLTAS QEAL 594 
Gene Ontology
 GO:0000159; C:protein phosphatase type 2A complex; IEA:InterPro.
 GO:0008601; F:protein phosphatase type 2A regulator activity; IEA:InterPro.
 GO:0007165; P:signal transduction; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR002554; PP2A_B56. 
Pfam
 PF01603; B56 
SMART
  
PROSITE
  
PRINTS