CPLM-014998

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-014998

UniProt Accession

SCMC2_HUMAN; Q6KCM7; Q5SYW7; Q5SYW8; Q5SYX3; Q5VWU2; Q5VWU3; Q5VWU4; Q6KCM4; Q6KCM6; Q6UX48; Q705K2; Q96PZ1; Q9BSA6

Genbank Protein ID

AJ619989; AJ619990; AJ619991; AJ619992; AJ619963; AB067483; AY358515; AK290705; AK290991; CH471090; AL360268; AL590708; AL360268; AL590708; AL360268; AL590708; AL360268; AL590708; AL590708; AL360268; AL590708; AL360268; AL590708; AL360268; AL590708; AL360268; BC005163; BC089448; BC103930; BC103931; BC103932; BC103933

Genbank Nucleotide ID

CAF04495.1; CAF04496.1; CAF04497.1; CAF04498.1; CAF04060.1; BAB67789.1; AAQ88879.1; BAF83394.1; BAF83680.1; EAW87739.1; CAH73133.1; CAH73133.1; CAH73134.1; CAH73134.1; CAH73135.1; CAH73135.1; CAH73136.1; CAH73136.1; CAI13826.1; CAI13826.1; CAI13827.1; CAI13827.1; CAI13836.1; CAI13836.1; CAI13838.1; CAI13838.1; AAH05163.2; AAH89448.1; AAI03931.1; AAI03932.1; AAI03933.1; AAI03934.1

Protein Name

Calcium-binding mitochondrial carrier protein SCaMC-2

Protein Synonyms/Alias

Mitochondrial ATP-Mg/Pi carrier protein 3; Mitochondrial Ca(2+)-dependent solute carrier protein 3; Small calcium-binding mitochondrial carrier protein 2; Solute carrier family 25 member 25

Gene Name

SLC25A25

Gene Synonyms/Alias

APC3; KIAA1896; MCSC3; SCAMC2; UNQ549/PRO1106

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
147	SLRDLGVKISEQQAE	ubiquitination	[1]
302	FMAYEQIKRLVGSDQ	ubiquitination	[1]
339	IYPMEVLKTRMALRK	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Calcium-dependent mitochondrial solute carrier. Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. May act as a ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria.

Sequence Annotation

DOMAIN 47 80 EF-hand 1.
DOMAIN 78 113 EF-hand 2.
DOMAIN 114 149 EF-hand 3.
REPEAT 184 270 Solcar 1.
REPEAT 278 363 Solcar 2.
REPEAT 375 463 Solcar 3.

Keyword

Alternative splicing; Calcium; Complete proteome; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

469 AA

Protein Sequence

MVSSVLCRCV ASPPPDAAAT AASSSASSPA SVGDPCGGAI CGGPDHRLRL WRLFQTLDVN 60
RDGGLCVNDL AVGLRRLGLH RTEGELQKIV QAGDKDLDGQ LDFEEFVHYL QDHEKKLRLV 120
FKSLDKKNDG RIDAQEIMQS LRDLGVKISE QQAEKILKSM DKNGTMTIDW NEWRDYHLLH 180
PVENIPEIIL YWKHSTIFDV GENLTVPDEF TVEERQTGMW WRHLVAGGGA GAVSRTCTAP 240
LDRLKVLMQV HASRSNNMGI VGGFTQMIRE GGARSLWRGN GINVLKIAPE SAIKFMAYEQ 300
IKRLVGSDQE TLRIHERLVA GSLAGAIAQS SIYPMEVLKT RMALRKTGQY SGMLDCARRI 360
LAREGVAAFY KGYVPNMLGI IPYAGIDLAV YETLKNAWLQ HYAVNSADPG VFVLLACGTM 420
SSTCGQLASY PLALVRTRMQ AQASIEGAPE VTMSSLFKHI LRTEGAFGLY RGLAPNFMKV 480
IPAVSISYVV YENLKITLGV QSR 503

Gene Ontology

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.
GO:0055085; P:transmembrane transport; IEA:InterPro.

Interpro

IPR011992; EF-hand-like_dom.
IPR002048; EF_hand_dom.
IPR002167; Graves_DC.
IPR002067; Mit_carrier.
IPR018108; Mitochondrial_sb/sol_carrier.
IPR023395; Mt_carrier_dom.

Pfam

PF13499; EF_hand_5
PF00153; Mito_carr

SMART

SM00054; EFh

PROSITE

PS00018; EF_HAND_1
PS50222; EF_HAND_2
PS50920; SOLCAR

PRINTS

PR00928; GRAVESDC.
PR00926; MITOCARRIER.