CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014238
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ski-like protein 
Protein Synonyms/Alias
 Ski-related oncogene; Ski-related protein 
Gene Name
 Skil 
Gene Synonyms/Alias
 Skir; Sno 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
349KIILEEMKEKFSMRNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May have regulatory role in cell division or differentiation in response to extracellular signals (By similarity). 
Sequence Annotation
  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 675 AA 
Protein Sequence
MENLQSKFSL VQGSNKKLNG MEDDGSPPVK KMMTDIHANG KTLTKVKKEH LDDYGDASVE 60
PDGEHAKRNR VSLPETLNLN PSLKHTLAQF HLSSQSSLGG PAAFSARYSQ ESMSPTVFLP 120
LPSPQVLPGP LLIPSDSSTE LTQTLLEGES ISCFQVGGEK RLCLPQVLNS VLREFSLQQI 180
NTVCDELYIY CSRCTSDQLH ILKVLGILPF NAPSCGLITL TDAQRLCNAL LRPRTFPQNG 240
SILPAKSSLA QLKETGSAFE VEHECLGKCQ GLFAPQFYVQ PDAPCIQCLE CCGMFAPQTF 300
VMHSHRSPDK RTCHWGFESA KWHCYLHVNQ KYLGTPEEKK LKIILEEMKE KFSMRNGKRI 360
QSKTDTPSGM ELPSWYPVIK QEGDHVPQTH SFLHPSYYLY MCDKVVAPNV SLTSAASQSK 420
EATKAETSKS TSKQSEKPHE SSQHQKTVSY PDVSLEEQEK MDLKTSRELY SCLDSSISNN 480
STSRKKSESA VCSLVRGTSK RDSEDSSPLL VRDGEDDKGK IMEDVMRTYV RQQEKLNSIL 540
QRKQQLQMEV EMLSSSKAMK ELTEEQQNLQ KELESLQSEH AQRMEEFYIE QRDLEKKLEQ 600
VMQQKCTCDS TLEKDREAEY AAQLAELRQR LDHAEADRQE LQDELRQERE ARQKLEMMIK 660
ELKLQIGKSS KPSKD 675 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0016605; C:PML body; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0046332; F:SMAD binding; IBA:RefGenome.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0001825; P:blastocyst formation; IMP:MGI.
 GO:0007050; P:cell cycle arrest; IMP:MGI.
 GO:0070306; P:lens fiber cell differentiation; IDA:MGI.
 GO:0002260; P:lymphocyte homeostasis; IMP:MGI.
 GO:0045596; P:negative regulation of cell differentiation; IDA:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IMP:MGI.
 GO:0050772; P:positive regulation of axonogenesis; IEA:Compara.
 GO:0070208; P:protein heterotrimerization; IEA:Compara.
 GO:0070207; P:protein homotrimerization; IEA:Compara.
 GO:0042981; P:regulation of apoptotic process; IMP:MGI.
 GO:0046677; P:response to antibiotic; IEA:Compara.
 GO:0007519; P:skeletal muscle tissue development; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IGI:MGI. 
Interpro
 IPR014890; c-SKI_SMAD4-bd_dom.
 IPR009061; DNA-bd_dom_put.
 IPR010919; SAND_dom-like.
 IPR003380; Transform_Ski.
 IPR023216; Tscrpt_reg_SKI_SnoN. 
Pfam
 PF08782; c-SKI_SMAD_bind
 PF02437; Ski_Sno 
SMART
 SM01046; c-SKI_SMAD_bind 
PROSITE
  
PRINTS