UniProt Accession

 IL18_HUMAN; Q14116; O75599; Q6FGY3; Q6WWJ7 

Genbank Protein ID

 D49950; AY266351; AF077611; AY044641; CR541973; CR542001; AP002007; AP002884; CH471065; BC007007; BC007461; U90434 

Genbank Nucleotide ID

 BAA08706.1; AAP92112.1; AAC27787.1; AAK95950.1; CAG46771.1; CAG46798.1; EAW67184.1; AAH07007.1; AAH07461.1; AAB50010.1 

Protein Name

 Interleukin-18 

Protein Synonyms/Alias

 IL-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma 

Gene Name

 IL18 

Gene Synonyms/Alias

 IGIF; IL1F4 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
115	STLSCENKIISFKEM	acetylation	[1, 2]
120	ENKIISFKEMNPPDN	ubiquitination	[3]
132	PDNIKDTKSDIIFFQ	acetylation	[2]
132	PDNIKDTKSDIIFFQ	ubiquitination	[3]
148	SVPGHDNKMQFESSS	ubiquitination	[4]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. 

Sequence Annotation

  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Cytokine; Reference proteome; Secreted. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IEA:Compara.
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005576; C:extracellular region; TAS:UniProtKB.
 GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
 GO:0005125; F:cytokine activity; TAS:UniProtKB.
 GO:0001525; P:angiogenesis; IDA:UniProtKB.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0071320; P:cellular response to cAMP; IEA:Compara.
 GO:0070301; P:cellular response to hydrogen peroxide; IEA:Compara.
 GO:0071346; P:cellular response to interferon-gamma; IEA:Compara.
 GO:0071260; P:cellular response to mechanical stimulus; IEA:Compara.
 GO:0071407; P:cellular response to organic cyclic compound; IDA:UniProtKB.
 GO:0071374; P:cellular response to parathyroid hormone stimulus; IEA:Compara.
 GO:0071375; P:cellular response to peptide hormone stimulus; IEA:Compara.
 GO:0071356; P:cellular response to tumor necrosis factor; IEA:Compara.
 GO:0042033; P:chemokine biosynthetic process; TAS:UniProtKB.
 GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IEA:Compara.
 GO:0048546; P:digestive tract morphogenesis; IEA:Compara.
 GO:0042253; P:granulocyte macrophage colony-stimulating factor biosynthetic process; TAS:UniProtKB.
 GO:0006954; P:inflammatory response; IDA:UniProtKB.
 GO:0042095; P:interferon-gamma biosynthetic process; TAS:UniProtKB.
 GO:0042231; P:interleukin-13 biosynthetic process; TAS:UniProtKB.
 GO:0042094; P:interleukin-2 biosynthetic process; TAS:UniProtKB.
 GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IDA:UniProtKB.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0000165; P:MAPK cascade; IMP:UniProtKB.
 GO:0001649; P:osteoblast differentiation; IEA:Compara.
 GO:0042104; P:positive regulation of activated T cell proliferation; IDA:UniProtKB.
 GO:2000504; P:positive regulation of blood vessel remodeling; IEA:Compara.
 GO:0032722; P:positive regulation of chemokine production; IEA:Compara.
 GO:0032967; P:positive regulation of collagen biosynthetic process; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; IEA:Compara.
 GO:0032725; P:positive regulation of granulocyte macrophage colony-stimulating factor production; IDA:BHF-UCL.
 GO:0050729; P:positive regulation of inflammatory response; IC:BHF-UCL.
 GO:0032729; P:positive regulation of interferon-gamma production; IDA:BHF-UCL.
 GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Compara.
 GO:0032740; P:positive regulation of interleukin-17 production; IDA:BHF-UCL.
 GO:0032757; P:positive regulation of interleukin-8 production; IEA:Compara.
 GO:2000256; P:positive regulation of male germ cell proliferation; IEA:Compara.
 GO:0032819; P:positive regulation of natural killer cell proliferation; IDA:BHF-UCL.
 GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara.
 GO:0051142; P:positive regulation of NK T cell proliferation; IDA:BHF-UCL.
 GO:0032930; P:positive regulation of superoxide anion generation; IEA:Compara.
 GO:0034105; P:positive regulation of tissue remodeling; IC:BHF-UCL.
 GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Compara.
 GO:0043117; P:positive regulation of vascular permeability; IEA:Compara.
 GO:0030155; P:regulation of cell adhesion; IDA:UniProtKB.
 GO:0009409; P:response to cold; IEA:Compara.
 GO:0055093; P:response to hyperoxia; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0009314; P:response to radiation; IEA:Compara.
 GO:0030431; P:sleep; ISS:UniProtKB.
 GO:0042088; P:T-helper 1 type immune response; IDA:UniProtKB.
 GO:0042092; P:type 2 immune response; TAS:UniProtKB. 

Interpro

 IPR008996; Cytokine_IL1-like.
 IPR000975; Interleukin_1.
 IPR015529; Interleukin_18. 

Pfam

 PF00340; IL1 

SMART

 SM00125; IL1 

PROSITE

  

PRINTS

 PR01933; INTRLEUKIN18.