UniProt Accession

 DEFM_HUMAN; Q9HBH1; Q8WUN6 

Genbank Protein ID

 AF239156; AF322879; BC019912 

Genbank Nucleotide ID

 AAG33968.1; AAK15624.1; AAH19912.1 

Protein Name

 Peptide deformylase, mitochondrial 

Protein Synonyms/Alias

 Polypeptide deformylase 

Gene Name

 PDF 

Gene Synonyms/Alias

 PDF1A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
240	FTNVYWMKVND****	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Removes the formyl group from the N-terminal Met of newly synthesized proteins (By similarity). 

Sequence Annotation

 ACT_SITE 215 215 By similarity.
 METAL 172 172 Iron (By similarity).
 METAL 214 214 Iron (By similarity).
 METAL 218 218 Iron (By similarity).  

Keyword

 3D-structure; Complete proteome; Hydrolase; Iron; Metal-binding; Mitochondrion; Polymorphism; Protein biosynthesis; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 243 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:HGNC.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0042586; F:peptide deformylase activity; IDA:HGNC.
 GO:0031365; P:N-terminal protein amino acid modification; IDA:HGNC.
 GO:0018206; P:peptidyl-methionine modification; IDA:HGNC.
 GO:0008284; P:positive regulation of cell proliferation; IMP:HGNC.
 GO:0006412; P:translation; IEA:UniProtKB-KW. 

Interpro

 IPR000181; Fmet_deformylase.
 IPR023635; Peptide_deformylase. 

Pfam

 PF01327; Pep_deformylase 

SMART

  

PROSITE

  

PRINTS

 PR01576; PDEFORMYLASE.